Discovering Hair Loss Treatments That Increase The Wnt/Beta-Catenin Signaling Pathway By High-Throughput Screening

April 2023 in “ Journal of Investigative Dermatology ”

G. Abudureyimu, D. Lee

Wnt/β-catenin signaling high-throughput screening natural products FDA-approved drugs HEK293 cells antiviral drugs anticancer drugs GSK-3b inhibitors Aminoacridine Abemaciclib Minoxidil hair regrowth hair loss Wnt/β-catenin pathway activation Rogaine

TLDR Aminoacridine and Abemaciclib, especially combined with Minoxidil, show promise for treating hair loss.

This study aimed to discover new drug candidates that activate Wnt/β-catenin signaling to treat hair loss by screening 2,600 natural products and 2,570 FDA-approved drugs. Using HEK293 cells for high-throughput screening, nine drugs were identified, including antiviral, anticancer, and GSK-3b inhibitors. Among these, Aminoacridine and Abemaciclib showed significant hair growth effects in animal experiments. Specifically, the combination of Aminoacridine with Minoxidil resulted in a 58% hair regrowth area at four weeks, compared to 41% for Minoxidil alone. These findings suggest that Aminoacridine, Abemaciclib, and their combination with Minoxidil are promising treatments for hair loss through Wnt/β-catenin pathway activation.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 759 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 679 upvotes 3 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Hair theory Scar tissue and Verteporfin

in Chat 24 upvotes 7 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 8 months ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 7 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

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