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research 1094 Discovering hair loss treatments that increase the Wnt/β-catenin signaling pathway by high-throughput screening

April 2023 in “Journal of Investigative Dermatology”

In this study, Aminoacridine, Abemaciclib, and the combination of Aminoacridine with Minoxidil showed potential for effective hair regeneration by activating Wnt/β-catenin signaling in animal experiments.

research High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth

March 2026 in “Communications Biology”

This study identified nine compounds that activate Wnt signaling, with aminoacridine and proflavine especially promoting hair and nail regeneration in mouse models, highlighting new therapeutic candidates from existing FDA-approved and natural compounds.

High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

research High-Throughput Screening for Discovering Small Molecules Capable of Increasing the Wnt/β-Catenin Signaling Pathway to Promote Hair and Nail Growth

June 2024 in “Research Square (Research Square)”

In this study, researchers identified nine FDA-approved drugs that activate the Wnt signaling pathway, with Aminoacridine, especially when combined with Minoxidil, showing promising effects on hair and nail growth in mice, suggesting potential treatments for hair and nail loss pending further clinical trials.

High-Throughput Screening of 3D Co-Culture Hair Follicle Mimetic Tissue with Enhanced ECM for the Screening of Hair Growth Promoting Compounds

research High-throughput screening of 3D co-culture hair follicle mimetic tissue with enhanced ECM for the screening of hair growth promoting compounds

January 2024 in “Biomaterials Research”

This study introduced a novel 3D co-culture system that effectively mimics in vivo extracellular matrix dynamics, supporting hair follicle biology research and providing a robust platform for evaluating hair loss treatments through enhanced epithelial-mesenchymal interactions.

research A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

9 citations , March 2017 in “Journal of Visualized Experiments”

This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.

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community Re:you (NOVOGRO) New Hair Loss Treatment Coming in August

45 upvotes 2 months ago

NOVOGRO's new hair loss treatment is questioned for its effectiveness compared to minoxidil, with skepticism about its claims and trial results. The product targets women and lacks the 5α-reductase inhibitor NV-1065, which is still in development.

community Why not just take the drugs before hair loss?

in Chat 123 upvotes 6 months ago

Finasteride and dutasteride are discussed as preventative treatments for hair loss, with some advocating for early use and others concerned about side effects, especially before full maturity. Many regret not starting these treatments earlier due to their effectiveness in preventing or slowing hair loss.

community Oral Minoxidil and the "Facial Bloating" - what the research actually says

43 upvotes 4 months ago

Oral minoxidil can cause rare facial bloating, especially at higher doses and in women. Reducing sodium intake, drinking more water, and adjusting the dose can help manage side effects.

community Latest study on creatine and hair loss. 45 men, 3 months.

378 upvotes 1 year ago

Creatine does not significantly affect DHT levels or cause hair loss. Some users continue using finasteride and minoxidil while taking creatine, expressing skepticism about its impact on hair loss.

community dut doomers - any photo evidence of people regrowing AFTER going back to fin?

in Finasteride/Dutasteride 23 upvotes 10 months ago

Some users experience worsening hair loss with dutasteride and improvement after switching back to finasteride, while others find better results with dutasteride. The effectiveness of treatments like finasteride, dutasteride, minoxidil, and RU58841 varies, requiring individuals to try different combinations or dosages to find what works best.

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Craig Bottomley-High
Studham, England, United Kingdom
13+ yrs

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Craig Bottomley-High