January 2024 in “Updates in clinical dermatology” Frontal fibrosing alopecia is a scarring hair loss condition mainly affecting postmenopausal women, with unclear causes.
5 citations
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March 2023 in “Archives of dermatological research” This study found that hidradenitis suppurativa is associated with increased serum levels of hypoxia-inducible factor-1α, suggesting its role in the disease's pathogenesis and as a treatment target.
January 2024 in “Journal of cellular immunology” This review explores the complex interactions of intrinsic and extrinsic mechanisms that regulate hair follicle stem cells and their role in skin homeostasis, aiming to advance understanding that could support future research on skin disorders.
28 citations
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March 2016 in “Toxicologic pathology” This review discusses the function and pathology of hair follicles and highlights the potential of using dogs as a model to study human hair and stem cell disorders, but presents no new experimental results.
4 citations
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February 2022 in “PeerJ” This study found that hair follicle mesenchymal stem cells improved liver function and pathology in a mouse model of liver cirrhosis, potentially by inhibiting the TGF-β/Smad pathway and reducing hepatic stellate cell activation.
February 2020 in “International Journal of Current Microbiology and Applied Sciences” This study found that canine hair follicle stem cells in vitro expressed markers associated with multipotency, suggesting their potential role in the hair cycle.
2 citations
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September 2024 in “Pharmaceuticals” This study suggests that human placenta hydrolysate reduces CFA-induced inflammatory pain in mice by inhibiting pro-inflammatory cytokines and protecting peripheral nerves.
25 citations
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April 2021 in “The EMBO Journal” This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.
1 citations
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March 2022 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that HIF-P4H-2 function in FoxD1-lineage cells is crucial for normal hair follicle development and homeostasis in mice, implicating disrupted HIF, TGF-β, and Notch signaling pathways in associated defects.
1 citations
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January 2020 in “Microscopy research” This study found that hair follicle stem cells from the bulge region in mice and humans can be isolated and cultured to maintain their phenotype and high proliferative capacity, suggesting their potential as an accessible source for tissue engineering and regenerative therapies.
20 citations
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July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
12 citations
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January 2012 in “Dermatology” Finasteride helped treat a 28-year-old's facial skin condition.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that impaired Nrf2 signaling and its relationship with keratin 16 may contribute to follicular hyperkeratinization and occlusion in hidradenitis suppurativa, opening new therapeutic avenues.
10 citations
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June 2023 in “Preprints.org” This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.
2 citations
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May 2017 in “International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences” This review discusses genetic mutations associated with Hutchinson-Gilford progeria syndrome and reports no clinical results; the authors emphasize the importance of cardiovascular monitoring in management.
August 2023 in “Diagnostics” This study observed that using ultra-high-frequency ultrasound with 70 MHz probes effectively assessed the distribution of hyaluronic acid fillers and improvements in nasolabial fold wrinkles, with significant changes in dermal thickness and wrinkle scores maintained 24 weeks after treatment.
135 citations
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October 2010 in “Stem Cells” This study found that stem cells from mouse hair follicles successfully reconstructed the ocular surface in most limbal stem cell deficiency mice, demonstrating potential for treating the condition in a mouse model.
1 citations
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February 2024 in “Journal of the European Academy of Dermatology and Venereology” Certain genetic factors may contribute to frontal fibrosing alopecia in Brazil.
22 citations
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March 2021 in “Journal of Cutaneous Medicine and Surgery” This review discusses the integration of ultrasound in dermatology for improved lesion visualization and diagnosis, highlighting recent technological advancements like handheld devices and high-frequency probes, and reports no clinical results.
April 2016 in “Journal of the American Academy of Dermatology” A 4-year-old girl had a rare hair disorder affecting only part of her scalp.
31 citations
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September 2020 in “Stem Cell Research & Therapy” Hair follicle stem cells may help repair the brain after a stroke.
7 citations
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July 2021 in “The Journal of Dermatology” This study in Asian females found that higher use of moisturizers and sunscreen among FFA patients may reflect appearance concerns rather than indicating a direct link to the disease mechanism.
3 citations
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May 2018 in “Experimental Dermatology” In this study, the researchers reported that patient impacts and symptoms of hidradenitis suppurativa, as assessed by HSIA and HSSA measures, are associated with clinical characteristics such as the number of abscesses and inflammatory nodules.
March 2022 in “Research Square (Research Square)” This study reported that pelage hair follicle mesenchymal stem cells isolated from mice using Ficoll Density Gradient Sedimentation can be obtained in large numbers and may promote hair growth via exosome secretion.
56 citations
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February 2013 in “International Journal of Molecular Medicine” This study found that human hair follicle-derived mesenchymal stem cells maintained their proliferation and differentiation potential when cultured with acidic fibroblast growth factor, basic fibroblast growth factor, or epidermal growth factor.
77 citations
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February 2001 in “Journal of Dermatological Science” HGF activator helps convert HGF to its active form, promoting hair growth.
2 citations
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July 2022 in “Stem cell research & therapy” This study found that a large number of pelage hair follicle mesenchymal stem cells can be efficiently isolated using two-step Ficoll Density Gradient Sedimentation, promoting hair growth by secreting exosomes in mice.
March 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” In this study, hair follicle stem cells were reported to accelerate burn wound healing and increase tissue tensile strength in rats.
316 citations
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June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that using a standardized protocol with microspheres of approximately 1.5 micrometers enhances penetration into hair follicles, particularly when skin is treated with cyanoacrylate skin surface stripping.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers created a comprehensive transcriptome map of human hair follicle compartments, identifying compartment-specific genes and providing a resource for potential therapeutic interventions.