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The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

This study revealed that deleting EZH2 in mesenchyme-derived cells of the female reproductive tract led to impaired uterine gland development and pregnancy loss in mice, highlighting EZH2's crucial role in fertility.

This case report describes a rare instance of hyperandrogenism and increased hirsutism associated with endometrial cancer in a postmenopausal woman, with symptoms resolving and androgen levels normalizing after a total laparoscopic abdominal hysterectomy and bilateral oophorectomy.

This study found that skin is a significant site for estrogen production in mice, impacting both hair cycle regulation and sensitivity to chemical carcinogenesis.

This case report highlights a rare ovarian steroid cell tumor as the cause of androgen excess in a 36-year-old woman and underscores the importance of thorough preoperative workup to avoid unnecessary surgery.

HPV infection is linked to better survival in advanced anal cancer, higher radiation doses improve survival, especially in HPV-negative patients, and prostaglandin E₂ pretreatment can protect mouse hair follicles from radiation damage.

In this study, researchers found that basal cell carcinomas with common Hedgehog signaling mutations may require additional mutations to hyperactivate downstream signaling and progress beyond dormancy.

This review examines the evaluation and management of hirsutism and hyperandrogenism in postmenopausal women and reports no new clinical findings.

In this case study, the researchers reported that treating a woman with type B insulin resistance using rituximab, dexamethasone, and cyclophosphamide greatly reduced her insulin needs, but her hyperandrogenic state persisted, suggesting ovarian hyperthecosis.

This study found that increased PSA levels in women with hyperandrogenism may serve as a diagnostic marker, comparable to free testosterone levels.

This case report details a post-menopausal woman with hirsutism and virilization due to rare Leydig cell tumors in both ovaries, underscoring the challenge of detecting such tumors with standard imaging.

This study found that HIF1 and mTORC1 signalling were active in both basal cell carcinoma and trichoepithelioma, but the pathways do not reliably differentiate between the two.

This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.

This case report describes a 23-year-old woman with an adult granulosa cell tumor of the ovary, whose symptoms and hormone levels improved significantly after surgical removal of the tumor.

This study found that the rs 1570360 polymorphism and the T-G-C haplotype of the VEGF gene may be associated with a protective factor against polycystic ovary syndrome in a Brazilian population.

This study found that K15 is a useful marker for investigating the role of stem cells in canine hair follicle tumours, while nestin is not optimal.

This review discusses the role of the hairless protein (HR) in alopecia and cancer, noting its potential importance in cancer cell growth and survival, and reports no new experimental results.

This study found that lower expression of VDR protein in breast cancer patients is associated with increased bone metastasis and poorer prognosis, making it a significant prognostic factor.

A new test helps find drugs to treat head and neck cancer by targeting c-Rel.

This study found that untreated hirsute patients have lower expression of type 2 17β-HSD mRNA in scalp hairs, indicating potential disturbances in androgen metabolism, compared to treated hirsute patients.

GLI2 activates GLI1, promoting skin tumor growth and hair development.

This review discusses the challenges and opportunities in targeting the hedgehog pathway for aggressive cancers, emphasizing the complexities of treatment resistance, immune response, and the potential of combining immune checkpoint inhibitors with hedgehog pathway inhibitors, but reports no new clinical results.

This study found that increased metastatic ability in colorectal cancer in a rat model was linked to changes in expression of multiple genes, including TGF-beta, PDGFb, and Rho B.

This study suggests that Merkel cell polyomavirus T antigen-positive cells resembling Merkel cell carcinoma may originate from epithelial cells in human hair follicles, potentially informing future transgenic mouse models for this cancer.

In this case report, the coexistence of hypercalcemia and androgen excess in a postmenopausal woman was linked to primary hyperparathyroidism and a suspected androgen-secreting ovarian tumor, underscoring the need for a comprehensive diagnostic approach to identify overlapping endocrine disorders.

This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.

This case report describes the first known instance of a testosterone-secreting steroid cell ovarian tumor causing pulmonary embolism and erythrocytosis in a postmenopausal woman, highlighting its potential role as a rare cause of hypercoagulable state.

This study reports that in a case of benign Brenner tumor, elevated androgens may originate from luteinized stromal cells, as these cells do not convert androgen to estrogen due to suppressed aromatase biosynthesis.

This study identified specific genes involved in radiation-induced fibrosis in skin, capsule, and muscle tissues of breast cancer patients, offering insights that may help improve mitigation strategies for these side effects.