A Hairy Situation: Ovarian Sex Cord Stromal Tumor As A Rare Cause Of Hyperandrogenism

    November 2022 in “ Journal of the Endocrine Society ”
    Hasan R. Syed, Lara Krusniak, Stephen Brietzke, Pak-Ho Au, Anota Akofu
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    TLDR A rare ovarian tumor caused high testosterone and excess hair in a woman, which was resolved after tumor removal.
    A 36-year-old female with a history of hirsutism and PCOS presented with elevated testosterone levels and a 12 cm adnexal mass on abdominal CT. Lab work suggested ovarian, not adrenal, origin for androgen excess. She underwent a right oophorectomy, and pathology confirmed a rare ovarian steroid cell tumor, NOS, with no metastasis. Post-operative testosterone levels decreased significantly, and hirsutism resolved. This case highlights the rarity of such tumors, comprising less than 0.1% of all ovarian tumors, and underscores the importance of thorough preoperative workup to identify the etiology of hyperandrogenism, which could prevent unnecessary invasive procedures.
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