Is This a Case of Androgen-Secreting Endometrial Cancer in a Postmenopausal Woman?

This case study describes a 56-year-old postmenopausal woman with a history of Type 2 Diabetes, obesity, and PCOS, who presented with increasing hirsutism and diffuse hair loss. Despite normal ovarian imaging, she was found to have elevated androgen levels and a uterine mass. A biopsy confirmed grade I endometrial adenocarcinoma. Following a total laparoscopic abdominal hysterectomy with bilateral oophorectomy, her androgen levels normalized, and hirsutism significantly decreased. This case highlights the importance of evaluating sudden androgenization in postmenopausal women for potential rare diagnoses like androgen-secreting tumors or endometrial cancer.