QS8: Analysis of the Whole Transcriptome in Breast Cancer Patients Undergoing Radiotherapy and Breast Reconstruction

July 2021 in “ Plastic and reconstructive surgery. Global open ”

Alexis Andrew Miller, Sujee Jeyapalina, Melena Garrett, Jay Agarwal

radiation-induced fibrosis keratinocyte differentiation fibroblast proliferation DNA damage response intermediate filament organization hair follicle morphogenesis

TLDR Radiation therapy in breast cancer patients changes gene expression related to DNA damage, fibroblast growth, and hair follicle development, which could help improve treatment for radiation-induced fibrosis.

This study analyzed the whole transcriptome in breast cancer patients undergoing radiotherapy and breast reconstruction to understand radiation-induced fibrosis (RIF). Seven patients were recruited, and tissue samples were collected and sequenced. The analysis identified significant genes and Gene Ontology (GO) terms in skin, capsule, and muscle tissues, revealing processes like keratinocyte differentiation, fibroblast proliferation, and DNA damage response. Notably, genes involved in intermediate filament organization and hair follicle morphogenesis were also identified, providing new insights into RIF development and potential mitigation strategies.

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