Impact of Biomarkers in Predicting Response to Adjuvant Chemotherapy and Overall Survival in Females with Breast Cancer: A Review

This review article discusses the impact of specific biomarkers on predicting the response to adjuvant chemotherapy and overall survival in females with breast cancer. It highlights that breast cancer is one of the most common cancers globally, with increasing mortality rates. Factors such as genetic mutations, hormonal instability, and improper use of chemotherapy contribute to these rates. Chemotherapy, while a common treatment, can have severe side effects, including immune system suppression and hair loss. Some patients do not benefit from chemotherapy due to the absence of certain genes. Recent studies have identified genes such as FKBP12, SAMAHD1, TRF2, CD155, and GATA3 as crucial in determining the effectiveness of chemotherapy and the progression of the disease. The review aims to investigate these five markers to predict the response to adjuvant chemotherapy by monitoring them through blood or tissue samples.