Prostate-Specific Antigen as a Diagnostic Marker in Female Hyperandrogenism

In 2013, a study with 30 premenopausal women with hyperandrogenism and 30 controls investigated the potential of prostate-specific antigen (PSA) as a diagnostic marker for hyperandrogenism in women. The study found that both PSA and free testosterone (FT) levels were significantly higher in women with hyperandrogenism, with PSA showing a sensitivity of 63.3% and specificity of 86.7% at levels greater than 0.02 ng/ml, and FT showing a sensitivity of 80% and specificity of 86.7% at levels greater than 4.00 pg/ml. There was a significant correlation between serum FT and PSA levels, but no significant difference in PSA levels across different grades of hirsutism, acne, or androgenetic alopecia. The study concluded that PSA could be used as a diagnostic marker for hyperandrogenism in women, but recommended further research with larger sample sizes to validate these findings.