17b-Estradiol Is Abundant in Skin and Regulates the Hair Follicle Cycle and Mirex Tumor Promotion

    January 2002 in “ NCSU Libraries Repository (North Carolina State University Libraries) ”
    Karen L. Porter
    Studysummary This study found that skin is a significant site for estrogen production in mice, impacting both hair cycle regulation and sensitivity to chemical carcinogenesis.
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    Research cited in this study 13

    1. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    2. Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle British journal of dermatology/British journal of dermatology, Supplement · 2000
    3. Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands Journal of Investigative Dermatology · 1998
    4. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    5. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    6. Evidence That Mirex Promotes a Unique Population of Epidermal Cells That Cannot Be Distinguished by Their Mutant Ha-ras Genotype Molecular carcinogenesis · 1997
    7. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996
    8. Localization and Expression of Cornifin-α/SPRR1 in Mouse Epidermis, Anagen Follicles, and Skin Neoplasms Journal of Investigative Dermatology · 1996
    9. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    10. Biochemical Mechanisms Regulating Human Hair Growth Skin Pharmacology and Physiology · 1994
    11. Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    12. Human Hair Growth In Vitro Journal of Cell Science · 1990
    13. Cyclic Changes in the Metabolism of Estradiol by Rat Skin During the Hair Cycle Journal of Investigative Dermatology · 1971