SUN-117: A Rare Case of Virilization in a Postmenopausal Woman with Concurrent Hypercalcemia
October 2025
in “
Journal of the Endocrine Society
”
Studysummary In this case report, the coexistence of hypercalcemia and androgen excess in a postmenopausal woman was linked to primary hyperparathyroidism and a suspected androgen-secreting ovarian tumor, underscoring the need for a comprehensive diagnostic approach to identify overlapping endocrine disorders.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case study discusses a 71-year-old postmenopausal woman with concurrent hypercalcemia and androgen excess, a rare combination that necessitates thorough diagnostic evaluation. The patient exhibited symptoms such as hirsutism, androgenic alopecia, and elevated androgen levels, alongside hypercalcemia and elevated parathyroid hormone levels, suggesting primary hyperparathyroidism. Imaging revealed a pelvic mass and ascites, indicating a potential ovarian tumor, possibly a Sertoli-Leydig cell tumor, while adrenal tumors were deemed unlikely. The case highlights the need for a systematic approach to diagnosing overlapping endocrine disorders, considering possibilities like paraneoplastic syndrome or MEN1. Pathological evaluation post-surgery is crucial for accurate diagnosis and management.
