Ovarian Hilus Cell Hyperplasia and Sertoli-Leydig Cell Tumor in a Patient with Postmenopausal Virilization: A Rare Case Report

A 71-year-old woman experienced postmenopausal virilization, presenting with symptoms such as hair loss, clitoromegaly, and hirsutism, which were found to be caused by ovarian hilus cell hyperplasia and a Sertoli-Leydig cell tumor. Her plasma testosterone levels were elevated, and imaging revealed a nodular formation in the right ovary and a cystic mass in the same location. She underwent a total laparoscopic hysterectomy and bilateral salpingo-oophorectomy. Pathology confirmed a poorly differentiated Sertoli-Leydig cell tumor in the right ovary and hilus cell hyperplasia in the left ovary. This case is notable because it involves the rare occurrence of both conditions in a postmenopausal patient, contributing to her virilization symptoms.