Ovarian Hilus Cell Hyperplasia and Sertoli-Leydig Cell Tumor in a Patient with Postmenopausal Virilization: A Rare Case Report

December 2021 in “ Aegean journal of obstetrics and gynecology ”

Begum Ertan, Eyüphan Ozgozen, Orkun İlgen, Göksenil Bülbül, Bahadır Saatli, Çağnur Ulukuş

hair loss virilization hirsutism ovarian hilus cell hyperplasia Sertoli-Leydig cell tumor testosterone clitoromegaly

TLDR A woman's male-like physical changes were caused by two rare ovarian conditions.

A 71-year-old woman experienced postmenopausal virilization, presenting with symptoms such as hair loss, clitoromegaly, and hirsutism, which were found to be caused by ovarian hilus cell hyperplasia and a Sertoli-Leydig cell tumor. Her plasma testosterone levels were elevated, and imaging revealed a nodular formation in the right ovary and a cystic mass in the same location. She underwent a total laparoscopic hysterectomy and bilateral salpingo-oophorectomy. Pathology confirmed a poorly differentiated Sertoli-Leydig cell tumor in the right ovary and hilus cell hyperplasia in the left ovary. This case is notable because it involves the rare occurrence of both conditions in a postmenopausal patient, contributing to her virilization symptoms.

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13 citations, January 1995 in “Postgraduate medicine”

Excessive hair growth in women can be harmless or signal serious health issues, and treatment often includes medication and hair removal, with noticeable results after 3-6 months.