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This study developed and tested a new injectable hydrogel for chronic diabetic wounds, reporting significant improvements in wound healing through enhanced angiogenesis, epithelization, and reduction of inflammation and infection in animal models.

This review highlights recent advances in hydrogel-based wound healing, noting that diverse hydrogel designs enhance healing and suggest potential for clinical translation, albeit with a need for more research on human applications.

In this study, researchers found that in growing skin tissue, epidermal wound healing occurs at the expense of normal skin development, as it impairs hair follicle growth and does not activate tissue morphogenesis genes.

In this study, bovine testes hyaluronidase accelerated wound healing in vitro and in vivo by enhancing cellular proliferation, reepithelialization, and modulating inflammation in rat models.

In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

This review explores the complex interactions between epidermal stem cells and their environment, highlighting the critical roles of these cells in skin wound healing and tissue repair processes.

This study suggests that a novel micropatterned dermal–epidermal matrix (μDERM) enhances keratinocyte function and epidermal morphology, offering potential improvements in skin substitute design for wound healing applications.

This study observed that a novel extracellular matrix hydrogel made from human fibroblast-derived matrix improved wound healing in animal models, showing significant effects such as hair follicle formation, reduced inflammation, enhanced pro-healing growth factor levels, and interaction with macrophages, compared to traditional collagen hydrogels.

This review discusses scaffold materials and properties used in epidermal tissue engineering to promote skin regeneration and reports no new research findings.

This review highlights the development and assessment of human-relevant models for cutaneous wound healing, emphasizing that a combination of systems, such as organoid platforms and skin-on-a-chip systems, is necessary to overcome limitations of traditional methodologies and address chronic wound challenges.

This study demonstrates that Sox11 and Sox4 are crucial for activating embryonic-like programs during wound healing, with Sox11 overexpression impairing skin differentiation and promoting genes linked to embryonic epidermis.

This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.

This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.

This article discusses the coordinated roles of different epidermal stem cells and other cell types in the skin's wound healing process and reports no new experimental results.

In an animal study, researchers observed that a Chromolaena odorata layered-nitrile rubber transdermal patch significantly improved wound contraction, protein, hexosamine, and uronic acid levels, and collagen deposition in healing excision wounds in rats compared to a control group with an empty patch.

This study introduces "Homeodynamic Rejuvenation" as a method to restore the skin's resilience by enhancing its ability to detect and recover from stress, focusing on five core biological processes critical for maintaining skin function and health amidst environmental and metabolic challenges.

This perspective reviews current knowledge about cellular and molecular mechanisms in wound healing from 2023–2025, highlighting inadequately understood pathways associated with conditions like keloids and chronic wounds, and discusses proposed novel therapies for these conditions.

This study observed that Althaea officinalis gel increased fibroblast populations, hair follicles, and vessel diameter in rat wounds, suggesting it might aid wound healing, though further clinical studies are needed.

In a murine burn wound model, this study found that an enhanced fractal self-pumping dressing significantly reduced wound area and tissue edema by efficiently draining excess exudates.

This study found that an injectable hydrogel, SF-g-SDA, outperformed commercial Tegaderm™ in healing wounds, promoting collagen deposition, and enhancing neovascularization in animal models.

This study reported that a novel bilayer wound dressing made from PLCL nanofibers and keratin hydrogel, loaded with FGF-2, promoted skin healing and showed potential for use in skin tissue engineering.

This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.

In this study, researchers developed a GelMA-based gradient pH hydrogel that effectively reduced bacterial load and promoted fibroblast and endothelial cell proliferation, macrophage polarization, neovascularization, and hair follicle regeneration, offering a promising treatment for bacterially infected skin wounds.

This review explores the potential of neuro-driven hydrogels for skin and nerve regeneration, integrating biochemical cues and advanced technologies like AI for personalized wound healing, but notes the need for further validation and trials before clinical use.

This study introduced a multifunctional DNA hydrogel dressing that may enhance wound healing by promoting tissue regeneration, nerve repair, and immune response in diabetic infectious wounds.

This study found that MED1 deficiency in keratinocytes accelerates skin wound healing in young mice but delays healing in older mice, suggesting differential roles in epidermal regeneration with age.

In this study, noncultured autologous skin cells prepared using a tissue homogenizer significantly improved burn wound healing in rats compared to a control treatment.

In this study, exosome-loaded hydrogels derived from skin precursor cells significantly improved wound healing in diabetic rats by enhancing angiogenesis, reducing inflammation, and promoting tissue repair.

In this study, researchers developed a self-assembling hydrogel called RADA-PDGF2 and found it to accelerate wound closure in a mouse model due to its pro-proliferative and pro-migratory properties, without causing cytotoxicity or immunogenicity.

This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.