research Cross-Sectional Survey Examining Skin Picking and Hair Pulling Disorders During the COVID-19 Pandemic
The COVID-19 pandemic increased symptoms in people with skin picking and hair pulling disorders.
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research Wound Healing and Skin Regeneration
Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla
Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.
research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation
HOXC13 is essential for hair and nail development by regulating Foxn1.
research Nail Whispers Revealing Dermatological and Systemic Secrets: An Analysis of Nail Disorders Associated With Diverse Dermatological and Systemic Conditions
Nails can reveal important health information about skin and body conditions.
research Compound Heterozygous Mutations in Forkhead Box N1 (FOXN1) Lead to Severe Immunodeficiency but Normal Hair and Nail Development in Patients
Mutations in the FOXN1 gene cause severe immune issues but don't affect hair and nails.
research Structure and Development of the Skin and Cutaneous Appendages
Understanding skin structure and development helps diagnose and treat skin disorders.
research TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition
The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
research The Role of Smads in Skin Development
Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.
research Expression and Function of Group IIE Phospholipase A2 in Mouse Skin
sPLA2-IIE is crucial for normal hair follicle structure and skin health.
research A Model System for Long-Term Serum-Free Suspension Organ Culture of Human Fetal Tissues: Experiments on Digits and Skin from Multiple Body Regions
Scientists developed a method to grow human fetal skin and digits in a lab for 3-4 weeks, which could help study skin features and understand genetic interactions in tissue formation.
research Development and Maintenance of Epidermal Stem Cells in Skin Appendages
Epidermal stem cells create and maintain skin structures like hair and nails through specific signaling pathways and vary by location and function.
research Deciphering Principles of Morphogenesis from Temporal and Spatial Patterns on the Integument
The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
research How Good Is Artificial Intelligence at Solving Hairy Problems? A Review of AI Applications in Hair Restoration and Hair Disorders
AI is effective in diagnosing and treating hair disorders, including detecting hair loss and scalp conditions with high accuracy, but it should supplement, not replace, doctor-patient interactions.
research Preparing the Hair Follicle Canal for Hair Shaft Emergence
A specific type of skin cell creates an opening for hair to grow out, and problems with this process can lead to skin conditions.
research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss
Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.
research Non-Rash Skin Toxicities Associated with Novel Targeted Therapies
Early recognition and management of skin side effects from new cancer therapies can prevent treatment delays.
research Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1
Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.
research Dermatologic Care of the Transgender Patient
Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.
research Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages
Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.
research The Epithelial Stem Cell Niche in Skin
Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
research Ocular Manifestation in Progeria: A Case Report
A boy with progeria had eye problems and signs of aging like hair loss and skin wrinkling.
research Histogenesis of Keratoacanthoma: Histochemical and Immunohistochemical Study
Keratoacanthoma comes from hair follicle cells.
research The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17
AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.
research Genetics of Structural Hair Disorders
The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.
research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies
Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.
research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia
Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.
research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage
Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.
research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles
Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?
Using neurohormones to control keratin can lead to new skin disease treatments.