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GlossaryCatagen Phase (hair regression phase)

hair growth stops and follicles shrink, lasting about 2-3 weeks

The Catagen Phase, also known as the Transitional Phase, is a short period in the hair growth cycle that lasts about 2-3 weeks. During this phase, hair growth stops, and the hair follicle shrinks and detaches from the dermal papilla, effectively transitioning the hair from the growth phase (Anagen) to the resting phase (Telogen). This phase is crucial for the renewal of hair follicles and the overall hair growth process.

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Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

research Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells

15 citations, May 2020 in “BMC complementary medicine and therapies”

Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

52 citations, May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression

2 citations, February 2019 in “Journal of Investigative Dermatology”

Higher levels of the DP2 receptor may lead to hair loss.

research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)

14 citations, January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.

research Low Versus High Fluence Light-Induced Hair Removal: How Hair Follicle Ex Vivo Studies Translate Into Clinical Results

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Higher fluence in hair removal damages hair follicles more, while lower fluence mimics natural hair regression, with long-term IPL treatments effectively reducing hair.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

research Human Hair Follicles Can Smell: OR2AT4-Mediated Hair Growth Regulation

August 2016 in “Journal of Investigative Dermatology”

Human hair follicles have a scent receptor that can influence hair growth.

research Signaling Networks Between Stem Cell Precursors, Transit Amplifying Progenitors, and Their Niche in Developing Hair Follicles

April 2016 in “Journal of Investigative Dermatology”

Blocking Prostaglandin D₂ (PGD₂) could help treat hair loss.

research Is Intrafollicular Autophagy an Essential Mechanism That Permits Human Hair Follicles to Remain in Prolonged Anagen In Vivo?

April 2016 in “Journal of Investigative Dermatology”

Autophagy, a cell recycling process, is crucial for prolonged hair growth and could be a potential target for treating hair growth disorders.

research Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling

25 citations, April 2015 in “Journal of Investigative Dermatology”

GasderminA3 is important for normal hair cycle transitions by controlling Wnt signaling.

Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

research Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

24 citations, December 2014 in “International Journal of Molecular Medicine”

Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.

research Inducible Deletion of Epidermal Dicer and Drosha Reveals Multiple Functions for miRNAs in Postnatal Skin

82 citations, March 2012 in “Development”

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

research Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells

11 citations, May 2022 in “Chinese medicine”

Alpinetin helps grow hair by turning on hair stem cells and is safe for use.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

28 citations, October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?

130 citations, December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle melanocytes die during hair regression.

Ginsenoside Re Prevents 3-Methyladenine-Induced Catagen Phase Acceleration by Regulating Wnt/Beta-Catenin Signaling in Human Dermal Papilla Cells

research Ginsenoside Re Prevents 3-Methyladenine-Induced Catagen Phase Acceleration by Regulating Wnt/Beta-Catenin Signaling in Human Dermal Papilla Cells

5 citations, November 2022 in “Journal of Ginseng Research/Journal of ginseng research”

Ginsenoside Re from Panax ginseng may prevent hair loss by maintaining autophagy and Wnt signaling in hair cells.

research Hair Growth Regulation by the Extract of Aromatic Plant Erica Multiflora

22 citations, March 2009 in “Journal of Natural Medicines”

Erica multiflora plant extract can help hair grow by stimulating growth-related cells and triggering hair cycle changes.

research Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12)

1 citations, August 2022 in “International Journal of Molecular Sciences”

FGF12 is important for hair growth and could be targeted for hair loss treatment.

research Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms

21 citations, January 2020 in “Pharmaceutical Biology”

Salvia plebeia extract can stimulate hair growth.

research Serum Ferritin and Vitamin D Levels Should Be Evaluated in Patients With Diffuse Hair Loss Prior to Treatment

6 citations, January 2020 in “Postepy Dermatologii I Alergologii”

Check and treat low iron and vitamin D levels in people with hair loss.

research Study of Hairfall Through Cohen Hair Loss Index With Reference to Different Temperaments

September 2023 in “International journal of Unani and integrative medicine”

Hair loss patterns are linked to temperament and can help diagnose it.

research A Review on Palitya and Dhatryadi Rasayana

June 2023 in “International journal of research in ayurveda and pharmacy”

Dhatryadi Rasayana, an Ayurvedic herbal mix, may be a safe and effective way to prevent premature hair greying.

research Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies

15 citations, June 2020 in “Experimental Dermatology”

Hormones and genes affect hair growth and male baldness.

Bioactives in Chinese Proprietary Medicine Modulate 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia

research Bioactives in Chinese Proprietary Medicine Modulate 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia

6 citations, April 2017 in “Frontiers in Pharmacology”

Chinese medicine may help treat hair loss by affecting genes and enzyme activity.

research CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

January 2024 in “International Journal of Molecular Sciences”

Blocking the protein CXCL12 with a specific antibody can increase hair growth in common hair loss conditions.

research Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

2 citations, January 2022 in “Skin Pharmacology and Physiology”

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

research Effects of Camellia Oleifera Seed Shell Polyphenols and 1,3,6-Tri-O-Galloylglucose on Androgenic Alopecia via Inhibiting 5α-Reductase and Regulating Wnt/β-Catenin Pathway

July 2024 in “Fitoterapia”

Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

research Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

5 citations, January 2021 in “Biomedicine & Pharmacotherapy”

Policosanol helps treat hair loss by balancing hormones and supporting hair growth.

research The Hair Cycle

375 citations, February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

124 citations, August 1994 in “Journal of Investigative Dermatology”

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.