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    Glossary Hair Bulb

    rounded base of the hair follicle where growth starts

    The hair bulb is the rounded, bulbous structure at the base of the hair follicle, located in the dermis layer of the skin. It is the site where hair growth begins, containing actively dividing cells that produce the hair shaft and the inner root sheath. The hair bulb also houses the dermal papilla, which supplies nutrients and signals necessary for hair growth.

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    1. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    2. Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors PLOS ONE · 2014 · 46 citations
    3. Cellular Activity in the Dermis Surrounding the Hair Bulb in Alopecia Areata Journal of Cutaneous Pathology · 1975 · 25 citations
    4. Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth International Journal of Nanomedicine · 2019 · 22 citations
    5. In vitro effects of testosterone, dihydrotestosterone and estradiol on cell growth of human hair bulb papilla cells and hair root sheath fibroblasts. Acta Dermato Venereologica · 1990 · 22 citations
    6. Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma American Journal of Pathology · 2016 · 20 citations
    7. The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients 2017 · 18 citations
    8. Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro British Journal of Dermatology · 1987 · 9 citations
    9. Effects of testosterone, dihydrotestosterone and estradiol on the growth behavior of cultured hair bulb papilla cells and root sheath fibroblasts 1989 · 5 citations
    10. “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women” Journal of Cosmetic Dermatology · 2019 · 3 citations
    11. Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation Folia Histochemica et Cytobiologica · 2011 · 3 citations
    12. A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice Biological & Pharmaceutical Bulletin · 2005 · 3 citations
    13. Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation International Journal of Pharmaceutics · 2021 · 2 citations
    14. Can a topical scalp treatment reduce hair bulb extraction? PubMed · 2007 · 2 citations
    15. DNA determination of human hair bulbs in normal and androgenetic alopecia Journal of Cutaneous Pathology · 1994 · 1 citations
    16. Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth DOAJ (DOAJ: Directory of Open Access Journals) · 2019
    17. 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion Journal of Investigative Dermatology · 2019
    18. Quantification of Squalene and Lactic Acid in Hair Bulbs with Damaged Sheaths: Are They Metabolic Wastes in Alopecia? Biomedicines · 2023
    19. Do Hair Bulb Melanocytes Undergo Apotosis During Hair Follicle Regression (Catagen)? 1998 · 130 citations
    20. Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation Journal of Investigative Dermatology Symposium Proceedings · 2001 · 19 citations
    21. [Skin-like structure generated from implantation of hair follicle bulb cells into collagen/chitosan porous scaffolds in vitro]. PubMed · 2004
    22. [Proliferation behavior of the anagen hair bulb in androgenetic alopecia before and after local administration of 17 alpha- propylmesterolone–DNA flow cytophotometry studies]. PubMed · 1990
    23. Eosinophils in fibrous tracts and near hair bulbs: A helpful diagnostic feature of alopecia areata Journal of The American Academy of Dermatology · 1997 · 64 citations
    24. 883 Hair follicle bulb developed as 3D scaffold free microtissue Journal of Investigative Dermatology · 2017
    25. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity International Journal of Molecular Sciences · 2023
    26. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity 2023
    27. Activation of the OVOL1-OVOL2 axis in the hair bulb and in pilomatricoma and pilomatrix carcinoma Journal of dermatological science · 2016
    28. Regional differences in the distribution of melanocyte-containing hair bulbs in the skin of male albino rats PLoS ONE · 2025
    29. Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles Journal of Dermatological Science · 2020 · 23 citations
    30. Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp Scientific reports · 2020 · 14 citations