DNA Determination of Human Hair Bulbs in Normal and Androgenetic Alopecia

    August 1994 in “ Journal of Cutaneous Pathology
    Alberto J. Villena, M. V. Alcaraz, I. Perez de Vargas
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    TLDR Hair loss happens due to faster cell growth and fewer cells in affected follicles.
    This study analyzed the DNA content of hair follicles in normal scalp and in scalps affected by androgenetic alopecia. The study found that affected follicles experience an acceleration of the mitotic rhythm, leading to an increase in hair in telogen and a widening difference in the anagen/telogen relationship. The decrease in the total number of cells within the matrix and papilla, combined with the acceleration of the cell cycle, leads to irreversible involution of the hair follicle.
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