Immunolocalization of Telomerases in Human Hairs Identifies Proliferating Cells in the Bulb Matrix and Outer Root Sheath

    March 2024 in “ Tissue and cell/Tissue & cell ”
    Lorenzo Alibardi
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    TLDR Telomerase-positive cells are mainly in the bulb matrix and outer root sheath of hair follicles.
    The study investigated the localization of telomerase-positive and proliferating cells in human hair follicles during different hair growth phases (anagen, catagen, and telogen). Using immunofluorescent and electron microscopy, the researchers analyzed 18 hair samples from three healthy individuals. They found that telomerase-positive cells are primarily located in regions with high cell proliferation, such as the bulb matrix and outer root sheath. Despite limitations due to the small sample size and incomplete hair compartments, the findings provide insights into the distribution of telomerase in hair follicles, suggesting its role in maintaining chromosome ends during cell proliferation.
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