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research Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath

March 2024 in “Tissue and cell/Tissue & cell”

This study found that in human hair bulbs, telomerase is present mainly in the nuclei of cells undergoing proliferation, particularly in the matrix epithelium during the anagen phase, and sparsely in the outer root sheath during late catagen and telogen phases.

research Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research

12 citations , January 2021 in “Journal of Investigative Dermatology”

This review discusses the role of telomere length dynamics in hair follicle biology and reports no new clinical findings, emphasizing the need for further research in humans.

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified 16 novel high sulfur KAP genes and two KAP pseudogenes on chromosome 21q23, showing expression in a specific region of the hair fiber cuticle.

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

This study identified a cluster of genes on chromosome 17 related to hair keratin-associated proteins, including 37 genes forming seven multigene families, localized in the hair shaft's upper cortex.

research A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice

60 citations , August 2008 in “Human molecular genetics online/Human molecular genetics”

This study suggests that a position effect disrupting TRPS1 expression may be linked to hypertrichosis in both Ambras syndrome in humans and a similar phenotype in Koa mice.

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community Anyone else find themselves staring at other men with full heads of hair?

in Chat 207 upvotes 9 months ago

A 19-year-old discusses feelings of envy towards men with full heads of hair, sharing their experience with hair loss since age 16. They have been using oral minoxidil and topical finasteride for two years, with initial improvement but continued shedding, and are considering switching to dutasteride.

community IVF process on Finasteride and effects of stopping finasteride.

138 upvotes 9 months ago

Concerns about finasteride affecting sperm quality and embryo abnormalities during IVF. The user plans to stop finasteride for 6 months and use minoxidil, microneedling, a red light cap, and saw palmetto shampoo to manage hair loss.

community Oral Minoxidil - Multiple Facial Hair in One Follicle / Pili Multigemini Question

in Minoxidil 117 upvotes 10 months ago

Oral minoxidil can cause multiple facial hairs to grow from one follicle, known as Pili Multigemini, leading to ingrown hairs and zits. Users report increased facial and body hair growth, with some experiencing fewer issues after switching to dutasteride.

community 1 Month on Dutasteride (0.5mg) + Supplements – Seeing Thickness But No New Hairs Yet. Is That Normal?

in Is this regrowth? 83 upvotes 1 year ago

A 31-year-old woman is using Dutasteride (0.5mg daily) and supplements like a multivitamin, Herbadal, pumpkin seed oil, and vitamin D for genetic hair loss, noticing thicker hair but no new growth after one month. She is considering adding minoxidil and is aware of Dutasteride's risks, especially regarding pregnancy.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 9 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

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