Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles for Effective Preservation and Delivery of Fermented Herbal Extract for Enlarging Hair Bulb and Enhancing Hair Growth
October 2019
in “
DOAJ (DOAJ: Directory of Open Access Journals)
”
poly(γ-glutamic acid) chitosan hydrogel nanoparticles fermented herbal extract 4HGF hair bulb hair growth encapsulation efficiency controlled release porcine skin telogenic mice dermal papilla cells hair follicles polyglutamic acid chitosan nanoparticles herbal extract encapsulation skin penetration
TLDR The nanoparticles effectively deliver herbal extract to enhance hair growth.
The study developed poly(γ-glutamic acid)/chitosan hydrogel nanoparticles to effectively preserve and deliver a fermented herbal extract (4HGF) for hair growth. The nanoparticles, approximately 400 nm in size, showed over 50% encapsulation efficiency and controlled release under physiological conditions. They successfully penetrated porcine skin and, when applied to telogenic mice and dermal papilla cells, resulted in enlarged hair bulbs and significant morphological changes, indicating potential for enhancing hair growth. This formulation could be a promising method for delivering hair growth-promoting compounds into hair follicles.