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GlossaryHaCaT keratinocytes

immortalized human skin cells used in research

HaCaT keratinocytes are a type of human skin cell that has been immortalized, meaning they can divide indefinitely in laboratory conditions. These cells are commonly used in scientific research to study skin biology, wound healing, and diseases like psoriasis and skin cancer because they closely mimic the behavior of normal human skin cells.

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Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

research Diphlorethohydroxycarmalol, Isolated from Ishige Okamurae, Increases Prostaglandin E2 through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes

9 citations, November 2012 in “Biomolecules & therapeutics”

A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.

research OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

6 citations, November 2022 in “Antioxidants”

OR2AT4 helps reduce aging and cell damage in human skin cells.

research Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin

196 citations, May 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sebocytes play a key role in controlling androgen levels in human skin.

research Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor

10 citations, February 2008 in “Photochemistry and photobiology”

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

research Eupafolin Nanoparticles Protect HaCaT Keratinocytes from Particulate Matter-Induced Inflammation and Oxidative Stress

43 citations, August 2016 in “International Journal of Nanomedicine”

Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.

research The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations, March 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research Ethanol Extract of Asiasari Radix Preferentially Induces Apoptosis in G361 Human Melanoma Cells by Differential Regulation of p53

2 citations, August 2019 in “BMC Complementary and Alternative Medicine”

Asiasari radix extract may be a potential treatment for melanoma because it selectively triggers cell death in melanoma cells by affecting p53 regulation.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations, December 2015 in “International Journal of Molecular Sciences”

PDCD4 is important for controlling skin cell growth and healing.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations, February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research Fisetin Promotes Hair Growth by Augmenting TERT Expression

22 citations, October 2020 in “Frontiers in Cell and Developmental Biology”

Fisetin, a type of polyphenol, may help hair grow by increasing certain protein activities in cells.

research Glutamic Acid Promotes Hair Growth in Mice

12 citations, July 2021 in “Scientific Reports”

Glutamic acid helps increase hair growth in mice.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

7 citations, February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

research Phloroglucinol Enhances Anagen Signaling and Alleviates H2O2-Induced Oxidative Stress in Human Dermal Papilla Cells

March 2024 in “Journal of Microbiology and Biotechnology”

Phloroglucinol may help improve hair loss by promoting hair growth and reducing oxidative stress.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro

32 citations, January 2007 in “Biological & Pharmaceutical Bulletin”

Minoxidil and retinol together help hair grow.

research Fullerene Nanoparticles in Dermatological and Cosmetic Applications

101 citations, October 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine”

Fullerenes show potential in skin care but need more safety research.

research Evidence for 1,25-Dihydroxyvitamin D3-Independent Transactivation by the Vitamin D Receptor

36 citations, February 2007 in “Journal of biological chemistry/The Journal of biological chemistry”

The vitamin D receptor can work without its usual activating molecule.

research Hydrobiome Of Thermal Waters: Potential Use In Dermocosmetics

June 2023 in “Cosmetics”

Thermal spring waters and their microbes could be good for skin health and treating some skin conditions in skincare products.

research Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

6 citations, May 2020 in “Nutrients”

Eating fewer calories may slow skin aging and improve skin health through various biological changes.

research Focus on Skin as a Possible Port of Entry for Solid Nanoparticles and the Toxicological Impact

62 citations, October 2010 in “Journal of biomedical nanotechnology”

Nanoparticles can enter the skin, potentially causing toxicity, especially in damaged skin.

research The Role of Integrin AlphaVbeta6 in Impaired Wound Healing and Hair Follicle Regeneration

January 2010

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

research The Role of Tight Junctions in Skin Barrier Function and Dermal Absorption

156 citations, August 2016 in “Journal of controlled release”

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Recent Advances on Skin-Resident Stem/Progenitor Cell Functions in Skin Regeneration, Aging, and Cancers and Novel Anti-Aging and Cancer Therapies

research Recent Advances on Skin-Resident Stem/Progenitor Cell Functions in Skin Regeneration, Aging, and Cancers and Novel Anti-Aging and Cancer Therapies

36 citations, September 2009 in “Journal of Cellular and Molecular Medicine”

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

research Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

24 citations, January 2020 in “International Journal of Molecular Sciences”

Some plants with flavonoids may help treat hair loss and promote hair growth.

research Heme Oxygenase and the Skin in Health and Disease

9 citations, July 2018 in “Current Pharmaceutical Design”

HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.

research The Effect of Topical RU58841 (Androgen Receptor Blocker) Combined with Minoxidil on Hair Growth in Macaque Androgenetic Alopecia

March 1998 in “Journal of Dermatological Science”

Combining RU58841 and minoxidil significantly increases hair growth.