Heme Oxygenase and the Skin in Health and Disease

July 2018 in “ Current Pharmaceutical Design ”

Imre Szabó, Anna Kenyeres, Andrea Szegedi, Attila Gábor Szöllősi

heme oxygenase HO-1 fibroblast proliferation keratinocyte proliferation wound healing oxidative stress psoriasis atopic dermatitis diabetic skin complications inflammation melanoma tumor growth Substance P curcumin skin microbiota

TLDR HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.

The document reviews the role of heme oxygenase (HO), particularly HO-1, in skin health and disease. HO-1 is involved in various skin functions and pathologies, including promoting fibroblast and keratinocyte proliferation, aiding in wound healing, and protecting against oxidative stress. It has therapeutic potential for skin conditions like psoriasis, atopic dermatitis, and diabetic skin complications, with studies showing that HO-1 induction can reduce inflammation and improve healing. However, HO-1 also has a dual role, as its overexpression in melanoma cells can lead to increased tumor growth and decreased survival. The enzyme's expression is influenced by oxidative stress and inflammation, and it can be induced by treatments such as Substance P and curcumin. The document suggests that while HO-1 is a promising target for skin disease treatments, more research is needed to fully understand its functions and to develop effective therapies. The skin microbiota's own HO enzymes are also identified as potential future targets for preventing or treating skin infections.

View this study on eurekaselect.com →

Discuss this study in the Community →

Similar Research

5 / 300 results

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

280 citations, July 2018 in “Antioxidants”

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

research Protective Effects of Melatonin on the Skin: Future Perspectives

44 citations, October 2019 in “International Journal of Molecular Sciences”

Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations, January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

research Gene Therapy to Enhance Angiogenesis in Chronic Wounds

36 citations, August 2022 in “Molecular Therapy — Nucleic Acids”

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

research Extracellular Vesicles in Facial Aesthetics: A Review

8 citations, June 2022 in “International Journal of Molecular Sciences”

Tiny particles called extracellular vesicles show promise for skin improvement and anti-aging in facial care but face challenges like low production and lack of research.