July 2026 in “Pharmaceuticals” This review highlights significant research trends and challenges in utilizing plant-derived extracellular vesicles for drug delivery and biomedical applications, emphasizing the need for standardized protocols and advanced purification technologies.
February 2026 in “Molecular and Cellular Probes” This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.
September 2025 in “Frontiers in Pharmacology” This study suggests that P. orientalis leaf-derived EVs could offer anxiolytic, antidepressant, and sleep-inducing benefits by affecting neurotransmitter levels and reducing inflammation, particularly when administered intranasally.
June 2025 in “Jundishapur Journal of Natural Pharmaceutical Products” This study optimized the extraction process and established quality standards for Pomelo peel essential oil from Vinh Long, Vietnam, identifying specific conditions that improved extraction yield and validating a high-precision method for limonene quantification.
February 2024 in “IntechOpen eBooks” This chapter reviews nutritional strategies for managing polycystic ovary syndrome, emphasizing dietary adjustments and lifestyle changes, but it does not report new clinical findings.
This article discusses the impact of hyperandrogenism in polycystic ovary syndrome on women's physical and mental health, but it reports no new experimental findings.
September 2025 in “Frontiers in Cell and Developmental Biology” This review highlights that exosome-like nanovesicles derived from traditional Chinese medicinal herbs show potential in enhancing wound healing processes such as inflammation resolution and angiogenesis, suggesting promising applications in skin regeneration and therapeutic development.
May 2022 in “Maǧallaẗ Buḥūṯ Al-Tarbiyyaẗ Al-Nawʿiyyaẗ (Print)” In this study, a high inositol diet, with or without supplements, significantly improved androgen levels, insulin sensitivity, and certain metabolic indicators in women with PCOS over three months.
182 citations
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December 2021 in “Cosmetics” This literature review discusses recent advances in using essential oils and their components in cosmetic products, highlighting their diverse benefits and challenges in formulation due to varying chemical profiles, as well as addressing safety considerations for these natural ingredients.
12 citations
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June 2024 in “Nutrients” In this review, researchers highlighted that natural polyphenolics like flavonoids and resveratrol may help enhance testosterone production in aging males by boosting the expression of the Star gene in Leydig cells, potentially preventing age-related degenerative conditions linked to testosterone insufficiency.
December 2024 in “Nutrients” In this review, skin changes like hair loss and brittle nails linked to nutritional deficiencies common in eating disorders are examined as critical diagnostic tools, highlighting the need for integrated care involving dermatologists, psychiatrists, and nutritionists for effective management.
September 2022 in “Tạp chí Y Dược học Cần Thơ” This study found that using grapefruit essential oil improved hair growth and length in a shaved white mice model compared to controls.
May 2023 in “Tạp chí Y Dược học Cần Thơ” In this study, researchers assessed the effects of a shampoo containing pomelo peel essential oil and Bồ Kết on hair growth in shaved white mice, finding it promoted faster, longer, and denser hair growth compared to untreated mice.
2 citations
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April 2020 in “Journal of Mind and Medical Sciences” This study reviewed reports on interactions between psychotropic drugs and natural beverages, finding that substances like grapefruit juice and St John's wort can significantly affect drug metabolism, emphasizing the need for physician-patient education on drug administration to prevent harmful interactions.
March 2026 in “Pharmaceutics” This review discusses the potential of plant-derived nanovesicles as natural therapeutics and drug delivery platforms in cancer therapy, highlighting their versatility and promising applications, but reports no new clinical results.
January 1999 in “Current Problems in Pediatrics” Swimming in Lake Malawi can lead to schistosomiasis, hepatitis B vaccine might cause temporary hair loss, and certain drinks affect kidney stone risk.
October 2012 in “Humana Press eBooks” This article discusses the historical and current uses of grape seeds in various industries but reports no new research findings.
64 citations
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October 1998 in “Acta dermato-venereologica” This study found that proanthocyanidins from grape seeds significantly promote hair follicle cell proliferation and hair cycle transition in mice, suggesting their potential as hair growth agents.
13 citations
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May 2019 in “Cancer Prevention Research” This study found that a three-month regimen of leucoselect phytosome, a grape seed extract complex, was well tolerated and significantly reduced bronchial proliferation markers in heavy active and former smokers.
9 citations
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April 2019 in “Food Chemistry” This study developed an efficient method for converting polymeric procyanidins into high-purity oligomeric procyanidins using a semisynthetic approach combined with separation techniques.
6 citations
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January 2021 in “Cellular and Molecular Biology” This study found that grape pomace from Georgian winemaking contains significant tocopherols and antioxidant activity, suggesting it could be a valuable resource for the pharmaceutical and food industries.
July 2026 in “Functional Foods in Health and Disease” In this study, oral administration of strawberry guava extract promoted hair growth in both mice and humans, with active components like adenosine, fructose, digalactosyldiacylglycerol, and pedunculagin contributing by enhancing skin blood flow and activating dermal papilla cells.
October 2025 in “Scientific Reports” This study found that grape leaves, especially from the 'Razaki' white cultivar, are rich in phenolic compounds and flavonols, suggesting potential use in developing functional products.
1 citations
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October 2021 in “Gene, cell and tissue” This study found that grape sap significantly improved hair growth and follicle health in male Wistar rats, suggesting its potential as a non-chemical treatment for hair loss.
January 2022 in “Advanced Pharmaceutical Bulletin” This study found that clove oil and LPGSE pretreatment increased finasteride skin permeability, while extending urea pretreatment reduced its penetration.
21 citations
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February 2023 in “Pharmaceuticals” This study reports that extracts from pomegranate leaves contain bioactive compounds with antioxidant, antimicrobial, and skin-beneficial properties, suggesting their potential use in nutraceutical and cosmeceutical applications.
53 citations
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July 2021 in “International Journal of Molecular Sciences” This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.
202 citations
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July 2022 in “Biomedicine & Pharmacotherapy” This review compiles and discusses the ethnomedicinal uses, pharmacological activities, and phytochemistry of pomegranate, suggesting potential future applications in drug discovery for various ailments but reports no new clinical results.
2 citations
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May 2025 in “ACS Food Science & Technology” This review examined recent biotechnological advances, including micropropagation and in vitro culture techniques, aimed at enhancing the production of beneficial metabolites in pomegranates, highlighting unexplored biosynthetic pathways and key enzymes involved in compound synthesis.
38 citations
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January 2013 in “Analyst” This study identified the main secondary metabolites in Ziziphus jujuba seeds and confirmed that UPLC-MS/MS and GC-MS effectively demonstrate their pharmaceutical quality.