Effect of Topical Grape Sap on Apoptosis in Hair Follicles Among Male Rats

The study investigated the effects of grape sap on hair follicle apoptosis in 126 male Wistar rats, which were divided into seven groups, including a control group, a bleomycin group to induce hair loss, various grape sap dosage groups (1, 10, and 100 mg/kg), a minoxidil group, and a combined minoxidil and grape sap group. After inducing hair loss with bleomycin, the rats were treated with grape sap for 21 days. The results indicated that grape sap treatment led to a significant increase in the number of follicles, sebaceous glands, and blood vessels, as well as hair growth length, total antioxidant capacity, and BCL2 gene expression compared to the bleomycin group. The study concluded that grape sap could potentially serve as a non-chemical treatment for hair loss by reducing apoptosis in hair follicle cells and stimulating hair growth, primarily due to its antioxidant content and the increased expression ratio of BCL2/BAX.