Effect of Topical Grape Sap on Apoptosis in Hair Follicles Among Male Rats

October 2021 in “ Gene, cell and tissue ”

Zahra Esmaeilzadeh, Ahmad Shabanizadeh, Zahra Taghipour, Reza Vazirinejad, Mohammad Reza Salahshoor, Mohammad Mohsen Taghavi

grape sap apoptosis hair follicle bleomycin minoxidil BCL2 gene BAX gene antioxidant hair growth sebaceous glands blood vessels Rogaine

TLDR Grape sap may help reduce hair loss and promote hair growth in rats.

The study investigated the effects of grape sap on hair follicle apoptosis in 126 male Wistar rats, which were divided into seven groups, including a control group, a bleomycin group to induce hair loss, various grape sap dosage groups (1, 10, and 100 mg/kg), a minoxidil group, and a combined minoxidil and grape sap group. After inducing hair loss with bleomycin, the rats were treated with grape sap for 21 days. The results indicated that grape sap treatment led to a significant increase in the number of follicles, sebaceous glands, and blood vessels, as well as hair growth length, total antioxidant capacity, and BCL2 gene expression compared to the bleomycin group. The study concluded that grape sap could potentially serve as a non-chemical treatment for hair loss by reducing apoptosis in hair follicle cells and stimulating hair growth, primarily due to its antioxidant content and the increased expression ratio of BCL2/BAX.

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Research cited in this study

research A Hairy Fall: Syncope Resulting from Topical Application of Minoxidil

research Hair Growth: Focus on Herbal Therapeutic Agents

research Chrysanthemum Zawadskii Extract Induces Hair Growth by Stimulating the Proliferation and Differentiation of Hair Matrix

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research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

research Procyanidin B-3, Isolated from Barley and Identified as a Hair-Growth Stimulant, Has the Potential to Counteract Inhibitory Regulation by TGF-β1

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research Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo

research Finasteride in the Treatment of Men with Androgenetic Alopecia

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