April 2025 in “International Journal of Scientific Research in Science and Technology” This review explores the therapeutic potential and diverse pharmacological properties of the tree Tectona grandis, highlighting its anti-ulcerogenic, antihyperglycemic, antifungal, and other activities, as well as recent advancements in using its extracts for metal nanoparticle synthesis with antimicrobial applications.
April 2025 in “Journal of Cosmetic Dermatology” This study evaluated a new AI-linked imaging device for grading dandruff severity, finding high correlation with expert assessments and suggesting its potential application in other skincare areas due to its versatility and ease of use.
March 2025 in “Molecules” This study explored the in vitro skin penetration of two compounds from Tectona grandis leaf extract used for standardization and found that compound 1 penetrates more efficiently than compound 2, especially with a propylene glycol enhancer.
February 2025 in “International Journal of Pharmaceutical Sciences Review and Research” In this study, researchers formulated and evaluated a herbal shampoo containing Tulsi leaves, Green gram extract, Flaxseed mucilage, and potato juice, finding it to possess good cleansing, foam stability, and conditioning properties, though further development is needed to enhance quality, performance, and safety.
January 2025 in “Antioxidants” In this study, repetitive subcutaneous administrations of a conditioned medium from stem cells significantly suppressed hair graying in mice exposed to X-ray irradiation, likely through antioxidative mechanisms involving HGF and potentially VEGF.
December 2024 in “Antioxidants” This study found that external and internal luteolin treatments reduced hair graying in model mice by mitigating age-related dysfunction in hair stem cell signaling, suggesting potential practical applications for anti-graying treatment in humans.
November 2024 in “Jurnal Biomedika dan Kesehatan” This study explores premature graying of hair, outlining potential causes such as genetic factors, nutritional deficiencies, and autoimmune disorders, and evaluates various management strategies including nutritional supplements, pharmacotherapy, and addressing underlying conditions.
November 2024 in “Stem Cell Research & Therapy” A new method improves the isolation of hair follicle cells for better hair growth research.
October 2024 in “JURNAL ILMU KEFARMASIAN INDONESIA” This study found that the F6 formulation of a hair tonic containing EDS and ATG extracts produced the most significant hair growth in rabbits, without causing skin irritation and remaining stable throughout the observation period.
October 2024 in “Jurnal Pharmascience” This study concluded that formulations of celery and candlenut extracts meet the necessary criteria for use as a spray preparation aimed at promoting hair growth, based on evaluations of physical properties and consistency.
October 2024 in “Journal of Cosmetic Dermatology” This study in Saudi Arabia found that 55.9% of participants reported premature graying of hair before age 30, with risk factors including genetic, health, and lifestyle aspects such as smoking, anxiety, nutrient deficiencies, and family history.
This study found that new methods for isolating human dermal papilla cells were more efficient than traditional methods, maintaining higher levels of specific markers and improving the cells' research potential.
September 2024 in “Ahmar Metastasis Health Journal” In this study on Wistar rats, ginger and celery extracts at the tested dosage did not significantly affect hair growth onset, duration, or regrowth, nor did they cause significant inflammation, despite the presence of bioactive phytochemicals in the extracts.
September 2024 in “Sasambo Journal of Pharmacy” This study formulated and tested a pomegranate leaf shampoo with antifungal properties, identifying an optimal composition of 5.5% SLS and 15.5% cocamide DEA, showing good foam stability, appropriate pH, and viscosity in lab tests.
September 2024 in “Journal of the American Academy of Dermatology” This study found that female pattern hair loss patients who used gratitude journals saw notable improvements in perceived hair loss and quality of life over one month compared to controls, with 83% reporting improvement in hair loss versus 33% in the control group.
June 2024 in “JURNAL PENDIDIKAN DAN KELUARGA” This experimental study evaluated celery extract as a hair tonic, finding it contains vitamin A and flavonoids. Organoleptic and pH tests indicated favorable smell, color, absorption, and user preference, supporting its potential as a natural ingredient for hair health applications.
May 2024 in “EAS Journal of Pharmacy and Pharmacology” In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.
May 2024 in “Academia Open” In this study, conducted on male Wistar rats, high doses of white turi flower extract significantly increased sodium and potassium kidney levels, causing symptoms like lethargy and hair loss without fatalities, suggesting potential acute toxicity that warrants further research for long-term safety assessment.
May 2024 in “Jurnal Lmu Farmasi dan Kesehatan/” In an experimental study, researchers evaluated shampoo formulations using celery leaf extract (Apium graveolens L) for hair growth and found that a 2% extract concentration provided the most favorable physical and chemical properties compared to other formulations.
May 2024 in “Journal of colloid and interface science” This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.
April 2024 in “International journal of clinical trials” In this study, researchers found that a standardized extract of Sesbania grandiflora (SesZen-Bio™) improved hair density and thickness, as well as increased serum ferritin levels, over an 8-week period among participants, suggesting enhanced keratin production and follicle growth.
April 2024 in “Nepal journal of dermatology, venereology & leprology” This article discusses the challenges in understanding and treating premature graying of hair and calls for more extensive research, reporting no new findings.
In this study, researchers found a strong association between premature graying of hair and deficiencies in vitamin D and B12, hypothyroidism, and deranged iron profiles, along with higher stress, altered appetite, smoking, and sleep pattern issues, significantly impacting quality of life.
March 2024 in “Journal of Evidence-Based Integrative Medicine” This study found that a hair tonic containing 1% teak leaf extract significantly increased hair growth and user satisfaction in men with androgenic alopecia after 24 weeks, without causing adverse effects, and was comparable to the standard treatment, minoxidil.
February 2024 in “Genes to Cells” This study observed that tooth loss in mice led to premature graying of hair in the interbrow region, which was possibly due to reduced stimulation of the trigeminal nerve, suggesting that decreased mastication could cause this type of hair graying.
February 2024 in “Trends in Sciences” This study examined the stability of two 5α-reductase inhibitors in Tectona grandis extracts, finding that they are more stable in acidic environments and degrade rapidly under heat and light unless protected, suggesting the need for careful storage when developing anti-hair loss medications.
January 2024 in “GeroScience” This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.
January 2024 in “Wiadomości Lekarskie” This source outlines the potential benefits and challenges of integrating advanced care at home programs with hospital medicine, highlighting their implications for healthcare systems and the necessary technological support. Results are not detailed in the abstract.
December 2023 in “Journal of Cutaneous Immunology and Allergy” In this case report, a 41-year-old male developed myasthenia gravis following alopecia areata, with prednisolone and tacrolimus improving his symptoms; a literature review identified 29 reported cases of this comorbidity, with some showing additional autoimmune diseases, suggesting a shared immunological mechanism.
October 2023 in “Regular and Young Investigator Award Abstracts” This study found that Baricitinib significantly reduced hair loss and immune response in a mouse model of alopecia areata.