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Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.

The document concludes that various childhood hair and nail disorders exist, some may improve on their own, and advances in genetics and immunology could enhance treatment and counseling.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

Redheaded people may have evolved to efficiently make vitamin D in areas with less sunlight.

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

AGA, a common hair loss, is caused by genetics, hormones, age, and environmental factors.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Swedish men with the E213 A-allele of the androgen receptor have a lower risk of prostate cancer.

Melatonin directly affects mouse hair follicles and may influence hair growth.

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The Rotterdam Study aims to understand various diseases in older adults.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.