Genotype Triad for HOTAIR rs10783618, LINC-ROR rs1942347, and MALAT1 rs3200401 as Molecular Markers in Systemic Lupus Erythematosus

    May 2022 in “ Diagnostics ”
    Nesreen M. Ismail, Eman A. Toraih, Amany I. Almars, Essam Al Ageeli, Manal S. Fawzy, Shymaa Ahmed Maher
    TLDR Certain genetic markers can indicate higher or lower risk for systemic lupus erythematosus.
    The study examined the association of three lncRNA polymorphisms—HOTAIR rs10783618, LINC-ROR rs1942347, and MALAT1 rs3200401—with systemic lupus erythematosus (SLE) in 163 patients and matched controls. It found that HOTAIR rs10783618*C/C and MALAT1 rs3200401*T/T were linked to increased SLE risk, while MALAT1 rs3200401*T/C was associated with decreased risk. HOTAIR rs10783618*C/C was also linked to arthritis and oral ulcers, and rs10783618*T/T was associated with hair loss, weight loss, and neurological symptoms. These findings suggest that HOTAIR and MALAT1 polymorphisms may serve as molecular markers for SLE susceptibility and severity.
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