Polymorphisms of the Genes ABCG2, SLC22A12, and XDH and Their Relation with Hyperuricemia and Hypercholesterolemia in Mexican Young Adults

    September 2021 in “ F1000Research ”
    Juan Manuel Vargas‐Morales, Martha Guevara‐Cruz, A. Celia, Lilia G. Noriega, Armando R. Tovar, Jorge Alejandro Alegría‐Torres
    TLDR The ABCG2 gene variant increases the risk of high uric acid and cholesterol, especially in overweight or obese young Mexican males.
    The study investigated the relationship between genetic polymorphisms and hyperuricemia in 860 young Mexican adults, finding that the ABCG2 (Q191K) polymorphism significantly increased the risk of hyperuricemia and hypercholesterolemia, particularly in males. Factors such as male sex, being overweight or obese, and having hypercholesterolemia or hypertriglyceridemia were also associated with hyperuricemia. The results highlighted the importance of the ABCG2 polymorphism as a genetic risk factor for these conditions in the studied population.
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