Polymorphisms of the Genes ABCG2, SLC22A12, and XDH and Their Relation with Hyperuricemia and Hypercholesterolemia in Mexican Young Adults

The study examined the association between genetic polymorphisms in the ABCG2, SLC22A12, and XDH genes and the prevalence of hyperuricemia and hypercholesterolemia in 860 young Mexican adults. It found that the ABCG2 (Q191K) polymorphism significantly increased the risk of both conditions, particularly in males, with a 2.43 times higher risk for hyperuricemia and a 4.89 times higher risk for hypercholesterolemia. The SLC22A12 (517G>A) polymorphism had a protective effect on LDL cholesterol levels but did not significantly impact uric acid levels, while the XDH (518T>C) polymorphism was not linked to hyperuricemia or metabolic syndrome components. The study suggested that genetic factors, along with sex and metabolic conditions, contributed to the predisposition to hyperuricemia and related cardiovascular risks, and emphasized the need for further research on genetic factors, lifestyle, and diet. Limitations included a small sample size and the analysis of only one polymorphism per gene.