Polymorphisms of the Genes ABCG2, SLC22A12, and XDH and Their Relation with Hyperuricemia and Hypercholesterolemia in Mexican Young Adults

The study examined the association between genetic polymorphisms in the ABCG2, SLC22A12, and XDH genes and the prevalence of hyperuricemia and hypercholesterolemia in 860 young Mexican adults. It found that the ABCG2 (rs2231142) polymorphism significantly increased the risk of hyperuricemia and hypercholesterolemia, especially in males, with a 2.43 times higher risk for hyperuricemia and a 4.89 times higher risk for hypercholesterolemia. The SLC22A12 (rs476037) polymorphism had a protective effect on LDL cholesterol levels, while the XDH (rs1042039) polymorphism showed no significant association with hyperuricemia or metabolic syndrome components. The study underscored the role of genetic factors in uric acid and cholesterol levels and suggested that carriers of the risk allele in the ABCG2 gene could be targeted in future pharmacogenetic research. Limitations included analyzing only one polymorphism per gene and using conservative hyperuricemia criteria.