A Mutation in MAP2 Is Associated With Prenatal Hair Follicle Density

November 2019 in “ The FASEB Journal ”

Yao Jiang, Yifan Jiang, Haihan Zhang, Mengran Mei, Hailiang Song, Xianghui Ma, Li Jiang, Zhenquan Yu, Qin Zhang, Xiangdong Ding

MAP2 microtubule-associated protein 2 hair follicle density hairless phenotype single nucleotide polymorphism valine-to-methionine substitution hair morphogenesis

Studysummary In this study, a missense mutation in the MAP2 gene was found to be associated with reduced hair follicle density, leading to the hairless phenotype in pigs.

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The study identified a mutation in the microtubule-associated protein 2 (MAP2) gene that was associated with hair follicle density in pigs, specifically a missense mutation of A-to-G at rs328005415, which resulted in a valine-to-methionine substitution. This mutation was linked to a hairless phenotype observed at a relatively high frequency in one pig herd. The research highlighted that the critical period for hair follicle formation in pigs occurred during embryonic days 39-45, with day 41 being particularly significant. The findings suggested that pigs could serve as a valuable model for studying hair morphogenesis and hair loss in humans due to the high genetic homology between the two species.

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