A Mutation in MAP2 Is Associated With Prenatal Hair Follicle Density

    November 2019 in “ The FASEB Journal ”
    Yao Jiang, Yifan Jiang, Haihan Zhang … Xiangdong Ding
    Studysummary In this study, a missense mutation in the MAP2 gene was found to be associated with reduced hair follicle density, leading to the hairless phenotype in pigs.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on faseb.onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 24

    1. Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS Scientific reports · 2019
    2. MiR-124 Promotes Neural Differentiation in Mouse Bulge Stem Cells by Repressing Ptbp1 and Sox9 Journal of cellular physiology · 2018
    3. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    4. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    5. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016
    6. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    7. LHX2 Is a Direct NF-κB Target Gene That Promotes Primary Hair Follicle Placode Down-Growth Development · 2016
    8. Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis Current Topics in Developmental Biology · 2016
    9. Inhibition of Wnt/β-Catenin Pathway Promotes Regenerative Repair of Cutaneous and Cartilage Injury The FASEB Journal · 2015
    10. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    11. The Immunology of the Porcine Skin and Its Value as a Model for Human Skin Molecular immunology · 2014
    12. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    13. To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders Seminars in Cell & Developmental Biology · 2013
    14. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    15. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    16. The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71 Mammalian genome · 2010
    17. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    18. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    19. Analyses of Regenerative Wave Patterns in Adult Hair Follicle Populations Reveal Macro-Environmental Regulation of Stem Cell Activity ˜The œInternational journal of developmental biology · 2009
    20. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    21. More Than One Way to Skin Genes & Development · 2008
    22. Porcine Epidermal Stem Cells as a Biomedical Model for Wound Healing and Normal/Malignant Epithelial Cell Propagation Theriogenology · 2006
    23. Alopecia Universalis Associated With a Mutation in the Human Hairless Gene Science · 1998
    24. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998

    Related research 5

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle Journal of Investigative Dermatology · 1994