Polygenic Control of the Wavy Coat of the NCT Mouse: Involvement of an Intracisternal A Particle Insertional Mutation of the Protease, Serine 53 (Prss53) Gene, and a Modifier Gene

January 2022 in “ Mammalian Genome ”

Masayuki Mori, Chang Liu, Takahiro Yoshizawa, Hiroki Miyahara, Jian Dai, Yuichi Igarashi, Xiaoran Cui, Ying Li, Xiaojing Kang, Keiichi Higuchi

Prss53 protease serine 53 intracisternal A particle polygenic chromosome 7 chromosome 9 curly hair gene expression knockout mice modifier gene curly hair gene wavy coat gene

Studysummary This study found that the wavy coat trait in Nakano cataract mice is polygenic, involving major and minor genes, and resembles human curly scalp hair associated with the PRSS53 gene alteration.

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