Sex Dependent Influence of a Functional Polymorphism in Steroid 5-Alpha-Reductase Type 2 (SRD5A2) on Post-Traumatic Stress Symptoms

    March 2013 in “ American Journal of Medical Genetics Part B Neuropsychiatric Genetics ”
    Charles F. Gillespie, Lynn M. Almli, Alicia K. Smith, Bekh Bradley, Kimberly Kerley, Daniel Crain, Kristina B. Mercer, Tamara Weiss, Justine Phifer, Yi‐lang Tang, Joseph F. Cubells, Elisabeth B. Binder, Karen N. Conneely, Kerry J. Ressler
    TLDR SRD5A2 gene variations affect PTSD symptoms differently in males and females.
    The study investigated the influence of a functional polymorphism in the SRD5A2 gene on post-traumatic stress symptoms, focusing on a specific SNP, V89L (rs523349), which affects testosterone to dihydrotestosterone conversion. Conducted on 1,443 traumatized African-American patients of low socioeconomic status, the research found a significant sex-dependent effect of the genotype on PTSD symptoms, particularly in males. The findings were confirmed through an internal replication sample and pooled analysis, highlighting that variations in SRD5A2 may affect PTSD severity and diagnosis risk in a sex-specific manner.
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