TLDR Genetic variations in FTO and MC4R may contribute to PCOS by affecting obesity.
This review article explored the relationship between certain gene polymorphisms, specifically FTO and MC4R, and Polycystic Ovary Syndrome (PCOS), a complex endocrine disorder. PCOS was associated with an increased risk of obesity and type 2 diabetes in women, with obesity and insulin resistance being common issues. The study suggested that genetic variations in FTO and MC4R, which were linked to obesity and metabolic disorders, might also be related to the development of PCOS through their effects on obesity/adiposity.
12 citations
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August 2019 in “BMC Medical Genetics” Certain MC4R gene variants are linked to higher BMI in obese women with PCOS but do not cause PCOS.
951 citations
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December 2013 in “Clinical epidemiology” PCOS is a common hormonal disorder in women that can be managed with lifestyle changes and various medications.
9 citations
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November 2012 in “Archives of Dermatological Research” MC4R gene variants not linked to female hair loss.
4809 citations
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January 2004 in “Fertility and Sterility” The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
12 citations
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August 2019 in “BMC Medical Genetics” Certain MC4R gene variants are linked to higher BMI in obese women with PCOS but do not cause PCOS.
129 citations
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January 2019 in “Clinical medicine insights” Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.
Genetic factors in PCOS are complex, with potential influences from the MC4R gene.
PCOS has a strong genetic basis, but more research is needed to fully understand it.
90 citations
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January 2021 in “Clinical Endocrinology” Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.
