The Impact of Certain Genetic Variants (Single Nucleotide Polymorphisms) on Incidence and Severity of COVID-19
January 2021
in “
The journal of gene medicine
”
TLDR Certain genetic differences may affect how likely someone is to get COVID-19 and how severe it might be.
The document from January 12, 2021, examined how single nucleotide polymorphisms (SNPs) in various genes may influence the incidence and severity of COVID-19. It suggested that SNPs in the ACE2 gene could explain the lower COVID-19 incidence in Africa versus Europe, while SNPs in the TMPRSS2 gene might account for the disease's higher severity in males. Additionally, SNPs in cytokine genes were linked to the intensity of the cytokine storm and the risk of severe outcomes like septic shock. The document emphasized the potential of genetic analysis in improving risk stratification and treatment planning for COVID-19 patients, although it did not specify the number of individuals studied for these genetic factors.
