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research Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing
This study found that in female mice, softer, lightly crosslinked gelatin-based hydrogels promoted better wound healing with less scarring and inflammation compared to stiffer, heavily crosslinked hydrogels, affecting immune and stromal cell behavior.
research Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering
This review discusses the potential of strontium-containing electrospun nanofibers for bone tissue engineering, outlining their effects on various cell types and highlighting current research challenges and future perspectives in the field.
research News
research Targeting of Skin Antigen-Presenting Cells
This study demonstrated that transcutaneous vaccination via cyanoacrylate skin surface stripping effectively induced both CD4 and CD8 T cell responses in humans, offering a promising alternative to intramuscular injection.
research Hair Stimulation with Pulsed Electric Fields
Low-dose pulsed electric fields in a rat model shifted hair follicles from resting to active growth, with voltage as the most influential factor.
research Biological Evidence of Improved Wound Healing Using Autologous Micrografts in a Diabetic Animal Model
This study in an animal model found that Rigenera® technology's use of autologous micrografts improved wound healing in diabetic rats by increasing factors like VEGF-A, IL4, and IL10 while reducing TNF-α and oxidative stress.
research IMMUNOTHERAPY OF CANCER: IMMUNE CHECKPOINT BLOCKERS, VACCINES AND ADOPTIVE T CELL THERAPIES
This study outlines new strategies for overcoming "cold" tumors, which are typically unresponsive to cancer immunotherapy, with approaches like dendritic cell-based treatments and local immune microenvironment modification, bolstered by both preclinical and clinical trial data.
research Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche
In a study using a rat model, researchers developed injectable hydrogels from antler reserve mesenchyme which enhanced regenerative healing of full-thickness cutaneous wounds by creating a fetal-like niche that increased stem cell presence and modulated gene expression related to wound healing.
research Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy
This review highlights the need for optimizing mesenchymal stromal/stem cell therapy through tailored in vitro strategies to unlock their full potential for treating specific diseases.
research Activation of TRPV4 Induces Exocytosis and Ferroptosis in Human Melanoma Cells
This study found that TRPV4 activation induced massive exocytosis and cellular changes associated with ferroptosis in melanoma cells, highlighting a potential role for TRPV4 in mediating these processes.
research Chemicals and Stem Cells in the Promotion of Regeneration
Chemicals and stem cells combined have advanced regenerative medicine with few safety concerns, focusing on improving techniques and treatment effectiveness.
research Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues
This review examines how biochemical and biophysical induction factors influence cell fate in tissue engineering and reports no new experimental results.
research STRESS AND AGING*
In this study, anabolic and catatoxic steroids were reported to prevent weight loss, tissue calcification, and cardiac necrosis in a rat model of disturbed calcium metabolism and progeria-like syndrome.
research Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles For Effective Preservation And Delivery Of Fermented Herbal Extract For Enlarging Hair Bulb And Enhancing Hair Growth
This study suggests that the hydrogel nanoparticle formulation of hair growth-promoting compounds may enhance hair follicle penetration and induce hair growth in tested models, demonstrating its potential as a hair growth treatment.
research Sound Wave‐Activated Self‐Powered Adhesive Dressing for Accelerated Wound Healing
In this study, a flexible adhesive self-powered wound dressing promoted skin regeneration and reduced inflammation in vivo using sound wave driving, without requiring skin bending or external devices.
research Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair
This study found that keratin intermediate filaments in the hair of GAN patients are altered, showing decreased diffraction signals and increased stiffness, strength, and extensibility.
research An Uncontrolled Innovative Test of Cryo-Chilled Carbon Dioxide as A Novel Amplification of a Nano-Botanical Multi-Acting Therapy in Advanced Stage Androgenetic Alopecia (Aga)
This study tested a novel cryo-carboxy dispensing device for treating androgenetic alopecia in six volunteers and found an unexpectedly rapid and positive response, with significant hair regrowth observed by day 90, prompting early conclusion of the trial.
research 115 AE法による実機水車発電機軸受の診断(セッション4 評価・診断II)
This study found that KSR1 is essential for v-Ha-ras-mediated skin tumor formation in mice but not for MT-driven mammary tumor genesis, suggesting its potential as a therapeutic target in Ras/MAPK signaling.
research Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination
This study found that transfollicular delivery using surfactant-based nanoparticles significantly enhanced antigen stability and immune response compared to other delivery methods, especially when combined with an adjuvant.
research Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing
In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.
research Combination of the stromal vascular fraction and platelet-rich plasma accelerates the wound healing process: pre-clinical study in a Sprague-Dawley rat model
This study found that the combination of stromal vascular fraction and platelet-rich plasma accelerated wound healing in rats more effectively than either treatment alone or saline.
research Carbon quantum dots applied to the chemical sensing of cobalt ions and methylcobalamin
This study found that Carbon Quantum Dots effectively detected and quantified Co²⁺ ions and methylcobalamin in tap water with high sensitivity and recovery rates between 95% and 105%.
research Mechano-encoding hydrogel microspheres for extracellular and pericellular matrix remodeling in musculoskeletal organoids
This review focuses on hydrogel microsphere-mediated strategies to improve organoid culture by addressing deficiencies in extracellular matrix organization, potentially enhancing the physiological accuracy and clinical translatability of osteomuscular in vitro models as reported in this study.
research Exploring in vitro markers of potency of extracellular vesicles from cardiosphere-derived cells in the treatment of cardiac ageing
This study found that extracellular vesicles derived from cardiosphere-derived cells classified as potent were effective in reducing cardiac hypertrophy and improving systemic health markers in rats with induced cardiac aging.
research Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management
This study reported that a new bioinspired injectable hydrogel, CQCS@gel, showed promise as a multifunctional wound dressing by achieving rapid hemostasis and promoting the healing of infected skin wounds in both in vitro and in vivo tests.
research Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis
This study found that hydrogels loaded with exosomes from bone marrow mesenchymal stem cells helped bone fracture healing by reducing inflammation, promoting blood vessel formation, and supporting bone regeneration, as confirmed in a mouse model.
research Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway
This study found that strontium ranelate promotes cartilage regeneration in rats by enhancing chondrogenic differentiation of bone mesenchymal stem cells while inhibiting the Wnt/β-catenin signaling pathway.
research Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing
The hydrogel dressing speeds up and improves diabetic wound healing.
research Calcium, Cobalt, Strontium, and Cerium-Based Binary Silicate Bioactive Nanoglasses: Rational Comparison in Bioactive Properties for Optimizing Tissue Repair Applications
This study synthesized and compared single-ion doped silicate bioactive glass nanoparticles for tissue repair, finding that BSr and BCe were most effective in accelerating wound healing and restoring vasculature, with BSr particularly reducing inflammation and BCo enhancing hair follicle regeneration but with limited biosafety window.