Strontium Ranelate Promotes Chondrogenesis Through Inhibition of the Wnt/β-Catenin Pathway

The study investigated the effects of strontium ranelate (SrR) on chondrogenesis and cartilage regeneration through the inhibition of the Wnt/β-catenin signaling pathway. Using bone marrow-derived mesenchymal stem cells (BMSCs) and a rat model with cartilage defects, SrR was applied via a silica nanosphere and GelMA scaffold system. The results showed that SrR inhibited the Wnt/β-catenin pathway, promoting chondrogenic differentiation and cartilage tissue regeneration. This suggested that SrR could be a promising alternative for cartilage tissue engineering and a potential treatment for conditions like temporomandibular joint osteoarthritis (TMJ-OA).