Diagnosis of Actual Turbine Generator Bearings Using AE Method (Session 4 Evaluation and Diagnosis II)

    November 2006 in “ 評価・診断に関するシンポジウム講演論文集 ”
    敏彦 古江, 充拡 末吉, 佳孝 内田, 信次 鹿毛, 一朗 奥, 康彦 脇部
    TLDR KSR1 is crucial for certain skin tumor formation and could be a cancer therapy target.
    In this study, researchers investigated the role of kinase suppressor of ras (KSR1) in Ras-mediated signaling pathways by generating KSR1-deficient mice. These ksr1-/- mice were viable and showed no major developmental issues, but they exhibited a disorganized hair follicle phenotype similar to epidermal growth factor receptor knockout mice, indicating that KSR1 is part of the same signaling pathway. The study found that KSR1 is essential for c-Raf-1 activation by epidermal growth factor but not for polyomavirus middle T antigen-driven mammary cancer, which was only moderately affected in ksr1-/- mice. However, KSR1 was crucial for v-Ha-ras-mediated skin tumor formation, as papilloma formation was completely inhibited in ksr1-/- mice. These findings suggested that KSR1 could be a potential therapeutic target for Ras/MAPK signaling in human cancers.
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