Mechano-Encoding Hydrogel Microspheres for Extracellular and Pericellular Matrix Remodeling in Musculoskeletal Organoids

July 2026 in “ Organoid Research ”

Xingkuan Wang, Jinping Chen, Jianye Tan, Shengwen Cheng, Lifu Jia, Charlotte A. E. Hauser, Tiziano Serra, Wei Huang, Yiting Lei, Pengcheng Xiao

Studysummary This review focuses on hydrogel microsphere-mediated strategies to improve organoid culture by addressing deficiencies in extracellular matrix organization, potentially enhancing the physiological accuracy and clinical translatability of osteomuscular in vitro models as reported in this study.

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