In Vitro 3D Organotypic Hair Follicle Model for High-Throughput Substance Testing

    September 2016 in “ Toxicology letters ”
    Flora Marta Kiss, T. Grix, Teresa DiColandrea, G Lindner, Reyk Horland, Roland Lauster, Uwe Marx, Beren Ataç
    Studysummary The researchers reported that hydrogels made from methacrylated glycol chitosan and hyaluronic acid with chondroitin sulfate may be suitable for load bearing soft tissue repair, showing enhanced chondrocyte viability and metabolic activity.
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    The study examined photo-cross-linked hydrogels made from methacrylated glycol chitosan (MGC), hyaluronic acid (MHA), and chondroitin sulfate (MCS) for use in load-bearing soft tissue repair. Hydrogels were tested for their mechanical properties, swelling behavior, and chondrocyte viability and metabolic activity. The 5050 MHA42MCS45 hydrogel blend showed promising results with high initial modulus, low swelling, and enhanced metabolic activity of encapsulated chondrocytes, suggesting its suitability for reparative load-bearing soft tissue constructs.
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