Giant Axonal Neuropathy Alters the Structure of Keratin Intermediate Filaments in Human Hair

    April 2017 in “ Journal of The Royal Society Interface ”
    Asfia Soomro, Richard J. Alsop, Atsuko Negishi … Maikel C. Rheinstädter
    Studysummary This study found that keratin intermediate filaments in the hair of GAN patients are altered, showing decreased diffraction signals and increased stiffness, strength, and extensibility.
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    Research cited in this study 7

    1. Structural Abnormalities in the Hair of a Patient With a Novel Ribosomopathy PLoS ONE · 2016
    2. Effect of Shampoo, Conditioner, and Permanent Waving on the Molecular Structure of Human Hair PeerJ · 2015
    3. The Structure of People's Hair PeerJ · 2014
    4. Characteristic Features of Ageing in Korean Women's Hair and Scalp British Journal of Dermatology · 2012
    5. Multiscale Modelling of Human Hair Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · 2004
    6. The Intermediate Filament Architecture as Determined by X-Ray Diffraction Modeling of Hard Alpha-Keratin Biophysical Journal · 2004
    7. Organization of Microfibrils in Keratin Fibers Studied by X-Ray Scattering Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1998

    Related research 1

    1. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002