Calcium, Cobalt, Strontium, and Cerium-Based Binary Silicate Bioactive Nanoglasses: Rational Comparison in Bioactive Properties for Optimizing Tissue Repair Applications

The study investigates the bioactive properties of calcium, cobalt, strontium, and cerium-based binary silicate bioactive nanoglasses (SBGNs) for tissue repair applications. The researchers synthesized four single-ion doped SBGNs and compared their bioactivities. BCa enhanced apatite nucleation, BSr showed strong anti-inflammatory activity, BCe exhibited significant antioxidant activity, and BCo promoted angiogenesis. In wound models, BSr and BCe accelerated wound closure and improved vasculature and hair follicle restoration, with BSr showing the greatest healing efficacy. BCo enhanced hair-follicle regeneration by 123% but had a narrow biosafety window. The study concludes that compositional simplification of SBGNs allows for ion-guided design and functional tuning, providing a framework for developing potent biomaterials for tissue repair.