Bioactive Glasses: Advancing Skin Tissue Repair Through Multifunctional Mechanisms and Innovations

This review highlights how silicate-based bioceramics and bioglasses could enhance skin regeneration for wound healing by promoting angiogenesis, stimulating collagen deposition, and providing anti-infection benefits, while also examining their integration with emerging technologies and current applications.

This review discusses the development of bioactive inorganic particles-based biomaterials for skin tissue engineering and reports no new results; the authors highlight potential future directions for these materials in wound management.

This study found that bioactive glass 1393 accelerates wound healing by promoting angiogenesis through the ROS/P53/MMP9 signaling pathway, enhancing granulation tissue formation and collagen deposition, as evidenced by both in vivo and in vitro experiments.

This study synthesized and compared single-ion doped silicate bioactive glass nanoparticles for tissue repair, finding that BSr and BCe were most effective in accelerating wound healing and restoring vasculature, with BSr particularly reducing inflammation and BCo enhancing hair follicle regeneration but with limited biosafety window.

This review examines the recent progress in using bioactive molecules for skin regenerative medicine and reports no new clinical results; the authors suggest this method could become a promising strategy for in situ skin regeneration.