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This study by Dr. Manka and colleagues reported that thyroid hormones play a significant role in regulating hepatic stellate cells, influencing liver fibrosis progression via TGFβ signaling. They found that TRα signaling might enhance scar-free tissue regeneration, offering potential pathways for targeted liver fibrosis treatments.

This study found that α-MSH acts as a modulator of inflammatory and fibrogenic responses in human fibroblastic skin cells, indicating potential therapeutic options for fibrotic skin disorders and inflammatory diseases of the hair follicle.

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

In this animal study, the researchers found that DPP4 plays a crucial role in scar formation and wound-induced hair follicle neogenesis in mice, impacting regenerative repair.

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

In this study, researchers found that electrospun membranes with aligned surface topography advanced the immune response towards an adaptive stage and highlighted the role of T cells in hair follicle regeneration in mice, showcasing the intricate interactions between immune and skin cells.

This review explores the novel roles of white adipose tissue in tissue homeostasis and regeneration, emphasizing its impact on epithelial, muscle, and immune tissues, and reports no new clinical results.

This review examines the complexities of age-related skin healing and discusses how translating findings from model organisms to humans could enhance understanding and treatment of impaired regeneration in aging populations, but it reports no new clinical results.

This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

SACUMAN, a rare condition causing hair loss without clear signs, is often misdiagnosed and needs scalp biopsies for accurate detection.

This article reviews skin regeneration and fibrosis, identifying key cellular and molecular players, and emphasizing the potential to manipulate the postwound environment to promote regeneration over fibrosis.

This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.

In this study, a wound-induced skin fibrosis model in mice revealed that TGFβ signaling plays a pivotal role in maintaining fibrogenic characteristics in dermal adipocyte progenitors, which could inform new therapeutic approaches for fibrotic skin conditions such as scleroderma.

This review discusses the development, lineages, functions, and roles of fibroblasts in fibrosis across four organs, highlighting their capabilities in tissue repair and contributions to fibrotic disorders when aberrantly activated, but it reports no new experimental findings.

This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.

This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.

This review discusses recent advances in scarless wound healing research, focusing on the roles of mechanobiology and immunology, and reports no new clinical results; the authors highlight the potential of next-generation human skin equivalents in understanding these mechanisms.

This review discusses the role of fibroblasts in treating diabetic complications and wound healing, highlighting their potential as immunomodulatory factors but provides no new clinical results.

PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.

This study identified dual epithelial and mesenchymal traits in dermal sheath cells during wound repair, suggesting they could be targeted to enhance healing.

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

This review summarizes the positive clinical response of using platelet-rich plasma as an adjuvant in skin rejuvenation treatments, with no identifiable complications, suggesting a promising outlook for its future use.

This review discusses mammalian models of epimorphic regeneration to define a vertebrate regeneration blastema, concluding that regenerative failure likely stems from cellular responses to the microenvironment after injury, not progenitor cell availability, and calls for targeted modification studies in mammals to advance human regeneration.

This review discusses the roles of several neuropeptides in skin-immune interactions and inflammatory responses, reporting no new results and emphasizing the need for further study in conditions such as psoriasis and dermatitis.

In this study, researchers used a mouse model to demonstrate that expression of MARCKSL1 in dendritic cells plays a crucial role in modulating fibrotic responses and scar formation during wound healing, suggesting that targeting this expression could offer new therapeutic strategies for scar prevention.

In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.

This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.

This review discusses the various roles of skin-resident dermal white adipose tissue in hair growth inhibition, antibacterial responses, and wound healing, reporting no new empirical findings.

This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.

This review discusses recent findings on the plasticity and regulation of epithelial stem cells and reports no new experimental results.