Role of Fibroblast DPP4 in Wound Healing, Scarring, and Regeneration
April 2018
in “
Journal of Investigative Dermatology
”
TLDR DPP4 is important for scarring and skin regeneration, and managing its activity could improve skin healing treatments.
The study investigated the role of fibroblast Dipeptidyl Peptidase 4 (DPP4) in wound healing and found that DPP4 is upregulated in the early stages of wounding but decreases during Wnt-activity and fibrogenic differentiation. Blocking DPP4 early in the wound healing process prevented wound induced hair follicle neogenesis (WIHN) and increased dermal thickness, whereas reduced DPP4 activity at later stages led to increased WIHN, indicating regenerative repair. These results suggest that DPP4 is crucial in scarring and regeneration, and understanding its mechanisms could lead to better skin regeneration therapies.
