TGFβ-Mediated Inhibition of Hypodermal Adipocyte Progenitor Differentiation Promotes Wound-Induced Skin Fibrosis

    July 2024 in “ Cell Proliferation ”
    Meimei Yin, Lixiang Sun, Shuai Wu … Ling‐juan Zhang
    Studysummary In this study, a wound-induced skin fibrosis model in mice revealed that TGFβ signaling plays a pivotal role in maintaining fibrogenic characteristics in dermal adipocyte progenitors, which could inform new therapeutic approaches for fibrotic skin conditions such as scleroderma.
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    Research cited in this study 14

    1. Dynamic Interplay Between IL-1 and WNT Pathways in Regulating Dermal Adipocyte Lineage Cells During Skin Development and Wound Regeneration Cell Reports · 2023
    2. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    3. Furnishing Wound Repair by the Subcutaneous Fascia International Journal of Molecular Sciences · 2021
    4. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    5. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    6. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    7. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    8. Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense Journal of Investigative Dermatology · 2019
    9. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta Immunity · 2018
    10. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 American Journal Of Pathology · 2016
    11. Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2016
    12. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    13. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    14. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007