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In this study, a wound-induced skin fibrosis model in mice revealed that TGFβ signaling plays a pivotal role in maintaining fibrogenic characteristics in dermal adipocyte progenitors, which could inform new therapeutic approaches for fibrotic skin conditions such as scleroderma.

This study found that inhibiting the enzyme PDE8A can promote adipocyte differentiation and enhance hair growth in an animal model of androgenetic alopecia, suggesting PDE8A as a potential therapeutic target for restoring dermal adipogenesis and hair cycling.

This study found that Dermal Fibroblast Progenitors have repressed chromatin profiles which hinder their ability to reform skin in allograft assays despite their differentiation potential.

Sca-1+ cells in newborn mouse skin may become fat cells.

This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.