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Mice without the p21 gene can fully regenerate injured ears due to reduced Sdf1 increase and leukocyte recruitment, suggesting new ways to induce tissue regeneration in mammals.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

Nail stem cells and Wnt signaling are important for fingertip regeneration but not sufficient for regenerating more complex limb structures.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

Boosting HGF signaling could improve the creation of hair follicles in lab-made skin.

Targeting the actin cytoskeleton could improve skin healing and reduce scarring.

BMP2 needs periosteal tissue to help regenerate mouse middle finger bones within a specific time.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Wnt signaling helps control how brain stem cells divide and is important for brain repair after injury.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.

Epithelial stem cells can adapt and help in tissue repair and regeneration.

Skin organoids from stem cells could better mimic real skin but face challenges.

Meis1 is crucial for skin health and tumor development.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Researchers identified specific genes that are important for mouse skin cell development and healing.

Melanocytes are important for skin and hair color and protect the skin from UV damage.

The research identified various cell types in mouse and human teeth, which could help in developing dental regenerative treatments.

Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

The conclusion is that grasping how cells determine their roles through evolution is key, with expected progress from new research models and genome editing.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Skin and hair renewal is maintained by both fast and slow cycling stem cells, with hair regrowth primarily driven by specific stem cells in the hair follicle bulge. These cells can also help heal wounds and potentially treat hair loss.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

Embryonic and adult stem cells are valuable for improving skin grafts and cell therapy.