88 citations
,
August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
65 citations
,
January 2018 in “Nature Reviews Endocrinology” This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.
62 citations
,
October 2017 in “JAMA facial plastic surgery” This study reported that using condensed nanofat combined with fat grafts significantly improved the aesthetic and functional aspects of atrophic facial scars in 20 patients, as assessed by both patients and plastic surgeons using the Patient and Observer Scar Assessment Scale.
55 citations
,
July 2020 in “International Wound Journal” This study evaluated the feasibility of a single-center, three-arm trial to assess fat grafting with or without PRP for diabetic foot ulcers, finding high patient engagement and indicating that a multi-center trial could be safe and feasible.
43 citations
,
June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.
35 citations
,
March 2014 in “British Journal of Dermatology” This study found that in androgenic alopecia, the arrector pili muscle degenerates and is replaced by fat, unlike in normal skin or telogen effluvium.
30 citations
,
July 1998 in “British Journal of Dermatology” This study found that in a rat skin model, fat cells inhibited the proliferation of organoid hair follicle cells and fibroblasts but may have accelerated hair follicle cell differentiation.
25 citations
,
June 2013 in “Obesity Reviews” This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.
24 citations
,
April 2017 in “Aesthetic plastic surgery” In this study, micro-autologous fat transplantation (MAFT) for frontal augmentation using the MAFT-GUN showed high patient satisfaction and no complications among 178 patients, suggesting it may be a reliable method for forehead contouring.
22 citations
,
October 2011 in “Bone” This study found that androgen signaling has complex effects on bone formation in male AR3.6-transgenic mice, with varying impacts based on the embryonic lineage of cells.
14 citations
,
September 2015 in “Ophthalmic plastic and reconstructive surgery” This case report concludes that the presence of distinctive histiocytic responses in a Cambodian woman's eyelid lipogranulomas suggests surreptitious silicone injections despite her denial of prior procedures.
14 citations
,
August 2014 in “Applied Physiology, Nutrition, and Metabolism” This study concluded that an 8-week low-starch/low-dairy diet increased fat oxidation in overweight and obese women with PCOS.
14 citations
,
October 2010 in “Dermatologic Surgery” This abstract is a placeholder and contains no research findings; it only includes journal-related navigation and subscription information.
13 citations
,
June 2019 in “Case reports in dermatology” This report presents the first known case of localized nonscarring and scarring alopecia following autologous fat grafting and reviews literature on alopecia caused by facial fillers, suggesting vascular compromise as a potential cause.
13 citations
,
February 2017 in “Science” Turning scar-forming cells into fat cells can reduce scarring.
9 citations
,
June 2020 in “Cell stem cell” This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.
8 citations
,
February 2020 in “Aesthetic Surgery Journal” This study found that early male hair loss treatment with Puregraft fat and low-dose adipose-derived regenerative cells increased terminal hair counts at 24 weeks compared to a saline control, indicating promise for androgenetic alopecia treatment.
8 citations
,
November 2010 in “Facial Plastic Surgery” This review discusses the limitations and techniques of fat transfer for facial rejuvenation, focusing on achieving safe and long-term aesthetic outcomes without providing new clinical results.
6 citations
,
July 2018 in “JAMA facial plastic surgery” This study found that injecting minced fat into the facial artery of rabbits was associated with higher rates of ophthalmic complications and mortality compared to fat granules or fat lipids.
6 citations
,
June 2018 in “Journal of Stomatology, Oral and Maxillofacial Surgery” In this cadaveric study, lipofilling was found easier to perform on the face than the scalp, whereas nanofat grafting was particularly suited for precise injections in scalp areas, suggesting a combination of techniques could aid in treating alopecia.
5 citations
,
January 2024 in “Aesthetic Surgery Journal Open Forum” This review notes that while ATX-101 showed a favorable safety profile for reducing submental fat in clinical trials, serious adverse events related to procedures have been reported in real-world use, prompting recommendations for improved management and prevention strategies.
4 citations
,
July 2023 in “Experimental Dermatology” This study found that incorporating human adipose subcutaneous tissue in 3D organotypic skin cultures mimicking hypertrophic scar conditions improved epidermal homeostasis, formed a basement membrane similar to native skin, and reduced myofibroblast presence, indicating an anti-fibrotic effect.
4 citations
,
May 2023 in “Plastic & Reconstructive Surgery” This study found that transplanting adipose tissue into the rat dorsum supported long-term skin expansion by enhancing thickness, vascularization, and cell proliferation, with adipose-derived cells actively contributing to skin regeneration and growth factor expression.
4 citations
,
February 2023 in “International Journal of Stem Cells” The FTO gene hinders stem cells in hair follicles from becoming pigment cells.
4 citations
,
September 1977 in “Lipids” This study observed that gerbils on a fat-deficient diet had altered fatty acid composition in various organs and exhibited hair loss, reduced testis development, and often lower body weight compared to those on a fat-supplemented diet.
3 citations
,
March 2023 in “Cell Biology International” In this study, ASC-enriched autologous fat grafting was found to be more effective and satisfying than conventional fat grafting for treating facial contour deformities with hyperpigmentation.
3 citations
,
December 2020 in “Journal of Cosmetic Dermatology” This study reported that autologous whole fat injection in the scalp considerably increased hair growth in patients with androgenetic alopecia.
3 citations
,
August 2017 in “Oral and Maxillofacial Surgery Cases” This study observed complete resolution of neuropathic pain symptoms in a patient after a fat grafting PRP procedure, suggesting it may be a less invasive treatment alternative.
2 citations
,
June 2020 in “Dermatologic Surgery” Fat grafting before hair transplant may improve hair growth in scarring alopecia.
2 citations
,
September 2019 in “Dermatologic Surgery” This retrospective study observed that hair grafting in burn and postskin graft scars, which preserve deeper skin layers, had more favorable outcomes than in scars extending to the subcutaneous layer.