Management of Serious Adverse Events Following Deoxycholic Acid Injection for Submental and Jowl Fat Reduction: A Systematic Review and Management Recommendations

This systematic review examines the management of serious adverse events (SAEs) following deoxycholic acid injections for submental and jowl fat reduction. It highlights the importance of adhering to standard procedures and suggests precautions such as avoiding intradermal injections and using lidocaine to prevent nerve damage. Common SAEs include hematomas and bruising in 72% of patients, with management strategies like compression therapy. Marginal mandibular nerve injury occurred in 4% of patients, resolving within 44 days. Transient alopecia was noted in 23.8% of male patients, resolving within 6 weeks to 12 months. The review stresses the need for proper patient assessment and treatment planning to prevent SAEs and optimize outcomes, recommending surgery for jowling caused by compartment displacement and cautioning against using ATX-101 for jowling due to subcutaneous tissue atrophy.