Deoxycholic Acid for Submental Fullness and More

This study found that deoxycholic acid effectively reduces excess fat under the chin, showing significant volume reduction and increased patient satisfaction in both aesthetic improvements and recovery experiences among the 13 participants.

This study reviewed various lipolytic agents for reducing submental fat and highlighted that while deoxycholic acid is FDA-approved, other compounds like phosphatidylcholine with deoxycholate lack cosmetic approval due to safety concerns. Understanding these agents' mechanisms and anatomy is crucial for safe fat reduction applications.

In this study, the authors reported that while deoxycholic acid effectively reduces submental fat, it can cause adverse effects such as edema, numbness, and skin necrosis, making knowledge of possible complications essential for clinicians.

This review notes that while ATX-101 showed a favorable safety profile for reducing submental fat in clinical trials, serious adverse events related to procedures have been reported in real-world use, prompting recommendations for improved management and prevention strategies.

This letter to the editor reports an observation of alopecia occurring after treatment with deoxycholic acid for reducing submental fat, but it presents no new clinical data or broader conclusions.